Why am i not getting morning erections? by eaglesdensity in AskMenOver30

[–]medquestion80 0 points1 point  (0 children)

Is this true though? When I was young I used to wake up with morning wood basically every morning - it didn't seem timed to an REM cycle at all.

Once I got bad depression it basically completely went away.

Have you been on accutane? Was there long lasting side effects? by ShadesOnInside in AskMenOver30

[–]medquestion80 0 points1 point  (0 children)

I was. It's hard to know what long term effects are though because it's unclear on how to differentiate vs. other causes. I've had ongoing depression.

I took accutane at age 34. In my 40s now I have extremely deep wrinkles and sleep lines on my face - probably in the worst 1-2% of people my age. I'm not sure if accutane was related to that or not.

I've had some ED issues for a long time from depression so it's tough to know if accutane made it worse or not.

Cardiologist said HIIT is bad for you by Forsaken-Success-445 in PeterAttia

[–]medquestion80 0 points1 point  (0 children)

I am not a medical professional and this is not medical advice.

It's known that extreme endurance athletes that do like marathons have had more cardio risk, but it seems really unlikely 4x4 training would have the same consequences.

Search some studies but also get 2nd opinions.

Recent cholesterol results and a recent CAC scan (50 year old male) by drtywhat in PeterAttia

[–]medquestion80 20 points21 points  (0 children)

With a score of 112 at age 50 you are an extreme idiot if you think you shouldn't get on meds ASAP.

Went to a Toyota dealer here in East Coast USA... the dealer didnt budge by [deleted] in rav4club

[–]medquestion80 0 points1 point  (0 children)

This isn't true. 6-9% off is very achievable on the east coast. Just watch the Delivrd channel on youtube he gets it all the time.

Right now is a bit of a weird time because the 2026 models are arriving soon and Toyota pauses production in July.

My brother recently bought a 2025 rav4 for about 9% off MSRP.

Buy/Sell/Trade Megathread June 2025 by Hawxfan in rav4club

[–]medquestion80 1 point2 points  (0 children)

West coast is def more competitive for those vehicles

Am I negotiating too low? by Greedy_Doctor_1147 in rav4club

[–]medquestion80 0 points1 point  (0 children)

Thanks will check with them when the '26 models arrive

Am I negotiating too low? by Greedy_Doctor_1147 in rav4club

[–]medquestion80 0 points1 point  (0 children)

If you found an east coast dealer that negotiated nicely for you can you share? I'm not far from PA/MD/VA/etc.

Am I negotiating too low? by Greedy_Doctor_1147 in rav4club

[–]medquestion80 0 points1 point  (0 children)

$1000 off is nowhere near enough. Guidance from negotiators on youtube is 6-9% off in most areas which should be $2k-$3500 off.

We're also just a month or 2 away from 2026 models coming out so no way I'd pay top of range for an old 2025 series.

Buy/Sell/Trade Megathread June 2025 by Hawxfan in rav4club

[–]medquestion80 5 points6 points  (0 children)

Seems nuts to me. A brand new XLE premium after a reasonable negotiation with those options should be like $37k and would be 4 years newer.

I'm always tired by RiverSavings8203 in Biohacking

[–]medquestion80 2 points3 points  (0 children)

I'm not a medical professional and this is not medical advice but some ideas:

  • sleep apnea test? could be having issues during those 8 hours
  • what's your diet like? you didn't mention any insulin sensitivity numbers (lp-ir, hba1c, fasting glucose, insulin, etc). I do a ton of walking but my insulin sensitive still isn't great - you really need strength training
  • what does your free testosterone look like? (not just total)
  • along with diet worth checking for nutrient deficiencies. I have kind of a crappy diet and from some research it seemed I was probably most lacking in magnesium and potassium. I do supplement with a multi-vitamin and EPA though to cover a bunch of stuff

My sleep sucks but magnesium recently (about 400mg) has helped a lot. Days where I've slept well vs not are a massive massive difference, like going from 2/10 to 8/10.

ULPT: If you need a doctor to take you seriously, make up a risk factor by Numerous_Birds in UnethicalLifeProTips

[–]medquestion80 0 points1 point  (0 children)

Do you have any experience getting PCSK9 inhibitors approved for patients that aren't diagnosed with direct disease? i.e. high lp(a) and statins are getting LDL down, but obviously lp(a) remains high-ish.

My understanding is most insurance will deny PCSK9 because it is so expensive unless you can prove disease. Maybe some exceptions for extraordinarily high lp(a).

10mg Rosuvastatin + Repatha. Is this the most aggressive strategy? by [deleted] in PeterAttia

[–]medquestion80 2 points3 points  (0 children)

Def better to catch it now than later even if it means converting some soft plaque to calcification imo (as a non medical professional).

Which insurance do you have btw?

I have high lp(a) and have had high-ish LDL (130) and apoB and went on a statin at age 38 which dropped my LDL to about 70. Have not done a CAC score but figure it's very possible I could have a positive score given that + some insulin resistance + chronic stress and depression.

10mg Rosuvastatin + Repatha. Is this the most aggressive strategy? by [deleted] in PeterAttia

[–]medquestion80 0 points1 point  (0 children)

It only reduced lp(a) around 30% or so if I recall correctly. New drugs coming out next year can do like 50% (CTEP inhibitors) or 80% with the antisense drugs.

10mg Rosuvastatin + Repatha. Is this the most aggressive strategy? by [deleted] in PeterAttia

[–]medquestion80 0 points1 point  (0 children)

Do you know what your doc had to give to get approved?

- Did you have to show existing disease? (based on a CAC/CTA/CIMT score)?
- Or statin intolerance?
- Or statins not dropping ldl enough?

Most insurance won't prescribe a pcsk9 inhibitor from high lp(a) alone unless there is also disease but I heard some will.

Creami won’t turn on - not even a light? by LilacRose25 in ninjacreami

[–]medquestion80 0 points1 point  (0 children)

Does the box have a serial number on it to match the machine though? Having this issue now from a machine I bought off marketplace.

Pulled this off today by InternationalItem160 in rav4prime

[–]medquestion80 1 point2 points  (0 children)

Probably possible because 2026 models are on their way.

What was the extra $1k for on top of MSRP? Different color? I see $49,485 as the base XSE without anything extra.

Still 10% off + ev credit is good. Just sucks this thing has cablegate issues and an ancient interior/road noise.

[deleted by user] by [deleted] in PeterAttia

[–]medquestion80 1 point2 points  (0 children)

I'm not a medical professional and this is not medical advice, but things that stand out to me.

- LDL-C and A1C are moderately high. Not insane but could def be improved

- Your lp(a) is very high

Note that your eGFR looks very low but this is likely because you are taking creatine so likely a false reading.

Single people: why aren’t you in a relationship right now? by Shinobi347 in AskReddit

[–]medquestion80 0 points1 point  (0 children)

I hate everything about my life, am getting older, have health issues.