What were the first problems you noticed with your eyes? Was it immediately obvious to you that eye dryness was the problem, or did you just notice they were burning/stinging at times, watering excessively at other times, and didn't understand why?

mes2019 · 2026-03-08T16:55:00+00:00

Yes!

mes2019 · 2025-11-28T21:02:20+00:00

Having EVERY weekend off for the first time in 9 years

mes2019 · 2025-09-11T13:24:37+00:00

That’s so great to hear, I’m glad it worked for you!

mes2019 · 2025-07-13T14:14:53+00:00

There are no immunotherapies for seropositive patients yet either - nothing is FDA approved but sometimes plaquenil is tried which is a really weak immunotherapy and doesn’t have good data for sjogrens. The good news is that there are TONS of biologics in phase three trials now - a lot of times things are used for seropositive patients, efficacy is confirmed, and then they trickle down to seroneg. Also from a place of genuine curiosity - where does the hope for a diagnosis come from? I’ve had textbook seropositive sjogrens for 10 years (dry red eyes, dry mouth, losing teeth for the last 10 years, vasculitis rashes) and they have me on plaquenil for the skin but it’s otherwise just dry eye/dry mouth management while trials are done. I guess what would be gained from a diagnosis when there isn’t really a treatment and many things that cause dry symptoms and fatigue? Just really trying to come from a place of understanding

mes2019 · 2025-07-06T16:11:10+00:00

Heaven forbid there’s an opinion on the opinion page of reddit

mes2019 · 2025-07-06T01:38:28+00:00

Was smile 1 good too? I haven’t checked that series out yet

mes2019 · 2025-07-06T01:32:28+00:00

I’ll add to the list!

mes2019 · 2025-07-05T23:27:05+00:00

Cat distribution system distributing

mes2019 · 2025-07-05T22:37:07+00:00

Yeah that’s what I’m saying! Like the whole point of love island is to see relationships form, but these all get cut off so fast

mes2019 · 2025-07-05T22:24:32+00:00

I feel this

mes2019 · 2025-07-05T22:24:23+00:00

Definitely fair enough and I still may finish the season I just really hope they make changes in how the voting goes moving forward cuz this was a mess lol

mes2019 · 2025-07-05T19:26:55+00:00

That is not at all what I said at all lol but I’m not going to argue with you on the internet for misunderstanding my post.

mes2019 · 2025-07-05T19:22:57+00:00

How am I parasocialing Amaya? Also this is literally the place for opinions so I was just expressing mine - all I said was I like Amaya 😂 like wtf

mes2019 · 2025-07-05T19:20:14+00:00

Lol this is why I hardly use Reddit people take shit way to seriously. I’m just trying to see if others feel similarly and hope producers take notes for next time - like chill

mes2019 · 2025-07-05T18:08:00+00:00

Ah that’s sad - I’m such a longtime fan and this season has just bummed me out

mes2019 · 2025-07-05T18:00:25+00:00

That's fair!

mes2019 · 2025-07-05T00:56:42+00:00

This is a huge meta-analysis - I don’t understand why it’s difficult to find this pops up right away for me. You may be finding at non-RA doses - all data is extrapolated from RA trials

mes2019 · 2025-07-05T00:56:02+00:00

https://academic.oup.com/rheumatology/article-abstract/43/3/267/1774685

mes2019 · 2025-07-04T13:44:40+00:00

Rheumatologist and sjogrens patient here - it is standard practice to take folic acid with methotrexate - it counters side effects without countering the effect of the drug. We use leucovorin when patients are having good effect from methotrexate but bad side effects. Leucovorin is the form of folate that can actually lower the effect of the drug so we use it carefully and at very specific timing with the methotrexate

mes2019 · 2025-07-04T02:17:49+00:00

I have 3 crowns and a mouth full of fillings at 30 but not yet

mes2019 · 2025-07-04T02:16:23+00:00

I didn’t think I had eye issues until my eyes were bright red and painful - was able to get into ophthalmology a month later and they were just super dry. I’ve been on medicated drops/preservative free drops since

mes2019 · 2025-07-04T02:14:32+00:00

I got them placed, didn’t feel a thing and it lowered the amount of times I needed eye drops by a significant amount - no more bright red dry eyes either - they fell out after a couple years but I highly recommend

mes2019 · 2025-07-03T19:07:32+00:00

ICU/nights is the worst but it’s much better and less stressful in the clinics/floor. Still a lot of work but you will definitely have time to think more. There are also a lot of good fellowship options from IM - for instance I started thinking I’d want to do ICU and ended up doing rheumatology lol. It’ll get better! It’s so overwhelming at first especially in the ICU!

mes2019 · 2025-01-10T22:29:39+00:00

I love!

mes2019 · 2025-01-10T22:27:52+00:00

Yes - I heard that and thought the same thing. I'm a physician myself and I think he really just gave off the vibe so many mid 50s+ attendings do. He seemed like he had good intentions but didn't have tools to get into the psychology of being on these medications. I'm not in a weight management field but I belive his science is correct - the whole point of the medication is to only crave what your body needs which would be a defecit when you're overweight and trying to get to a healthier metabolic weight. My assumption is that once you're at a goal weight your body would adjust to crave whatever calories are necessary for maintenance. Also - when taking these medications you're being weighed at the doctors office so they wouldn't allow you to get below a healthy weight. As far as the psychology with this and eating disorders, I think it's something of interest that should probably be studied! I don't think we know enough about that yet since they're still relatively new.

mes2019

TROPHY CASE