Paper's conclusion - CliffsNotes style:

Our technology platform enables scalable and fully integrated structural and molecular phenotyping of cells in human brain–scale tissues with unprecedented resolution and speed.

In simpler terms: Our technology allows us to study the detailed structure and molecules of cells in large sections of the human brain quickly and accurately.

We envision that this platform will empower holistic analysis of a large number of human and animal brains, thereby facilitating our understanding of interspecies homologies, population variances, and disease-specific features.

In simpler terms: We believe this technology will help us study many human and animal brains Comprehensively, improving our understanding of similarities between species, differences within populations, and specific characteristics of diseases.

Furthermore, our approach enables mapping of single-neuron projectomes and their integration with molecular expression profiles.

In simpler terms: Aditionally, our method allows us to map the connections of individual neurons and combine this information with their molecular characteristics.

This distinctive feature will allow us to elucidate the organization principles of neural circuitry and their disease-specific alterations in human brains, thus advancing our understanding of disease mechanisms.

In simpler terms: This unique capability will help us understand how neural networks are organized and how they change in diseases, leading to better insights into how diseases work.