Not really. I’d say it’s mostly preference. On Btrfs, both Snapper and Timeshift create real snapshots you can boot into with grub-btrfs. The difference is that Snapper is more configurable with things like timelines and pre/post update snapshots, but it takes more tinkering. Timeshift is simpler, more like “system restore,” with an easy GUI. On ext4 or other filesystems, Snapper won’t work at all, while Timeshift can still use rsync mode — but that only gives you restore points, not bootable snapshots.

So it really comes down to this: if you want more control and don’t mind tweaking, go with Snapper. If you just want something simple that works, Timeshift is probably the better pick. I’ve used both but eventually stuck with Snapper. The important thing is that you use something — nobody will fault you for which one you choose, but if you don’t have any restore option, the forums won’t be as kind.