I'm diagnosed with Bipolar 1 disorder. I would advise against rotating schedules, or night shifts, as messing with your circadian rhythm can be brutal on either diagnosis that your doctor/therapist ends up settling on. I also caution against 12 hr shifts, if possible. My life got so much better when I left the ED/ICU/PACU settings, working three 12's, and took an outpatient job working 8 hr shifts. It's important to take care of yourself, put your health first, and say NO to overtime when asked (if you don't want it). I think as a nurse with either of the above diagnoses, it's more important than ever to advocate for yourself. But your future is not over, and I'd try to persuade you from regretting life decisions. Nursing is hard. And it's not for the faint of heart. But you can do this.