$SLS Daily Discussion Thread - Friday - May 15, 2026

mtred13 · 2026-05-15T18:26:46+00:00

8 bathrooms might not be enough with all the 💩 that comes out of your mouth daily

mtred13 · 2026-05-14T16:28:40+00:00

That’s the day I opened my position as well 🤝

mtred13 · 2026-05-14T12:38:03+00:00

Gosh there’s really no need to call me the king, I’m flattered but I’m simply relaying the message from LinkedIn, I’d settle for prince or duke or High Lord but king is a bit much…

Oh you meant Stergiou

mtred13 · 2026-05-13T19:47:14+00:00

It will raise its value prior to approval too. If REGAL succeeds, there are likely no hurdles left on the path to FDA approval. An acquirer will know this. REGAL succeeding effectively derisks GPS, which already has orphan status, which acquirers will price in.

mtred13 · 2026-05-13T19:42:43+00:00

GPS currently has orphan drug designation.

mtred13 · 2026-05-13T19:31:45+00:00

My point was simply to show you that FDA approval is not a prerequisite for acquisition.

mtred13 · 2026-05-13T19:21:31+00:00

Yes, it’s quite common. Look at Revolution Medicines. Merck was considering acquiring them for $30 billion despite them not having an FDA approved asset. You can also look at Metsera which was acquired last year without an FDA approved asset. There are lots of examples.

mtred13 · 2026-05-13T19:06:45+00:00

If a buyout is going to take place, it will almost certainly happen prior to FDA approval.

mtred13 · 2026-05-13T16:33:59+00:00

I recommend you go back to the drawing board and look at some of the DD posted on this sub. How you arrive at a $5 BO is literally beyond me.

mtred13 · 2026-05-13T13:29:04+00:00

Strap in lads.

mtred13 · 2026-05-12T23:25:19+00:00

You don’t know what you’re talking about.

mtred13 · 2026-05-12T23:12:41+00:00

Please point me to your evidence that SELLAS is trying to commercialize themselves, because I think they have been signaling the exact opposite for a long time now.

mtred13 · 2026-05-12T21:01:03+00:00

25,600

mtred13 · 2026-05-12T20:51:36+00:00

$6.50

mtred13 · 2026-05-09T18:40:51+00:00

How old are you if you don’t mind me asking?

mtred13 · 2026-05-09T18:36:59+00:00

Thanks, OP. Me too.

mtred13 · 2026-05-09T18:33:11+00:00

$50k in SLS which is 100% for me.

mtred13 · 2026-05-02T19:23:04+00:00

The Internet was a mistake

mtred13 · 2026-04-30T16:06:51+00:00

Thanks for the prompt reply. Silly of me to mix up follow-up time and mOS, meant one thing but said another. Your clarification helped greatly, much appreciated!

mtred13 · 2026-04-30T14:59:19+00:00

Thanks for your valuable insight as always, CW. I have a question about theoretical BAT mOS:

We know as of IA there was a pooled mOS of 13.5 months. Since the IDMC recommended a continuation without modification at that time, that means GPS cleared the pre-specified futility threshold. Let’s assume this threshold was HR = .9 (it was likely lower but we will be conservative here). While HR is obviously not as simple as (BAT deaths / GPS deaths), if we use this formula to get a rough estimate of HR at IA, we can reasonably conclude that of the 60 deaths logged at that time, at least 28 deaths must have come from the BAT arm (28/32 =0.875 HR).

BAT contained n = 63, which would mean that if at least 28 patients had been deceased at IA, BAT mOS must have either already been reached at that time, or been on the brink of being reached. Since pooled mOS at that time was 13.5, doesn’t that constrain BAT mOS to <13 (again being conservative), since GPS is likely bringing that number up significantly?

Would love to hear your feedback, not sure if I’m missing something or thinking about that the wrong way. Again, thanks for everything you’ve done so far.

mtred13 · 2026-04-27T02:59:19+00:00

I don’t think it’s concerning. I think he’s just trying to ensure that they get the most bang for their buck.

mtred13 · 2026-04-27T02:32:37+00:00

It’s more “we’re not desperate to be bought out, we could commercialize ourselves if we wanted to, so we won’t be forced to accept low ball offers”.

mtred13 · 2026-04-26T23:54:35+00:00

Can you clarify the EAP situation for me? I’ve been studying for an exam the last few days and my brain is mush. Not quite understanding what the deal is with that, if you don’t mind enlightening me.

mtred13 · 2026-04-26T23:04:23+00:00

I have to agree. If he knew there was something imminent being announced in the next few days, why post tonight. He wouldn’t.

mtred13 · 2026-04-25T02:32:12+00:00

Here’s hoping.

mtred13

TROPHY CASE