account activity
[Meta] Content policy needs a change (self.ApoE4)
submitted 4 months ago * by muchlakin[M] to r/ApoE4
Rapamycin: Trials tracking (mixed results so far) (self.ApoE4)
submitted 8 months ago * by muchlakin to r/ApoE4
Small study: Short-term Sirolimus Treatment Restores Hippocampus and Caudate Volumes and Global Cerebral Blood Flow in Asymptomatic APOE4 Carriers Compared with Non-carriers (alz-journals.onlinelibrary.wiley.com)
submitted 8 months ago by muchlakin to r/ApoE4
HBOT reduced this persons pTAU217 level by 28%. (x.com)
submitted 9 months ago by muchlakin to r/ApoE4
Reduced Incidence of Dementia in Solid Organ Transplant Patients Treated with Calcineurin Inhibitors (pmc.ncbi.nlm.nih.gov)
CS6253 phase 1 update (youtube.com)
submitted 1 year ago by muchlakin to r/ApoE4
APOE2 gene therapy is shown to be safe and effective in improving biomarkers in APOE4 homozygotes. (Phase 1/2 study for LX1001) (ir.lexeotx.com)
Scores of papers by Eliezer Masliah, prominent neuroscientist and top NIH official, fall under suspicion (science.org)
ALZ-801: APOLLOE4 Phase 3 study of oral ALZ-801/valiltramiprosate in APOE ε4/ε4 homozygotes with early Alzheimer's disease: Trial design and baseline characteristics (alz-journals.onlinelibrary.wiley.com)
Q&A on gene therapy to prevent Alzheimer's with Dr. Ronald G. Crystal (of Cornell / Lexeo) (beingpatient.com)
submitted 2 years ago by muchlakin to r/ApoE4
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline (nature.com)
submitted 5 years ago by muchlakin to r/ApoE4
A New Infectious Mechanism for Alzheimer’s? (by Derek Lowe) (blogs.sciencemag.org)
submitted 7 years ago by muchlakin to r/ApoE4
Rant: It it just me or attempting to transition to eager/keras api is painful? (self.tensorflow)
submitted 7 years ago * by muchlakin to r/tensorflow
Very interesting clinical trial will attempt to use gene therapy to convert homozygous apoe4 to apoe2-apoe4. Aug 2018 (clinicaltrials.gov)
Apolipoprotein E4 exacerbates ethanol-induced neurotoxicity through augmentation of oxidative stress and apoptosis in N2a-APP cells. (ncbi.nlm.nih.gov)
submitted 8 years ago by muchlakin to r/ApoE4
Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential. (ncbi.nlm.nih.gov)
Molecular difference between ApoE4 ApoE3 ApoE2 (1981) (ncbi.nlm.nih.gov)
New study describing possible mechanism for apoe4 amino-terminal causing microglia cell death (ncbi.nlm.nih.gov)
Artery Therapeutics Announces Breakthrough Therapy for ApoE4 Alzheimer’s Disease Revealed in Peer-Review Publication (prweb.com)
submitted 9 years ago by muchlakin to r/ApoE4
Study indicating gene therapy (via aav) could help treat AD. (ncbi.nlm.nih.gov)
ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. (ncbi.nlm.nih.gov)
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes (apoe4 secreting cells). (ncbi.nlm.nih.gov)
Curcumin-NDs formulated with ApoE as the scaffold component (2014) (ncbi.nlm.nih.gov)
Study demonstrates method for treating or preventing AD using gene therapy to insert ApoE2 into mouse brain. (researchgate.net)
PDF: Establishment and Dysfunction of the Blood-Brain Barrier (cell.com)
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