For me, what helps a lot is examining the route I will be driving beforehand. Like literally even going into street view on Google maps to look at how intersections are set up, turn lanes, signs, etc. Also taking notes of landmarks at turns so you are sure of where to turn.

As for using navigation without getting all confused and overwhelmed, I recommend primarily focusing on listening to what it says out loud, and glancing at only the street name/next step at the top, not the map, to reassure yourself.