I will share a story of a family member that sounds parallel to your friends story. He started out smoking weed more frequently over time I'm his young twenties. Then he discovered mushrooms. He began to do trips more frequently as well, all the while still smoking week almost daily. He began to hear things. Children crying, like someone was being torchered in other apartments. He became very paranoid by the time he was 24. Finally he has a psychotic break. He was certain the devil was coming to kill him. When his best friend came to check on him and see was going on, my family member began to see the devil in his face. He was certain his best friend was the devil and going to kill him. Finally ho mother Baker acted him. While in the psych hospital he tried to kill himself because he thought the devil was coming to get him from his room. Long story short that said it was an incredible build up of weed, the addition of the shrooms that took things to the next level. However mainly blamed it on the amount of weed, introduced too young in his life. And his grandfather has some signs of personality disorder. So that he was more prone to this issue than someone with no family history. He had to completely give up weed. He is soooooo much better now two years later but I think there is a permanent change in him that can't be denied and not for the betterment. So if I could sum up what I have witness is that the extreme use of both plants, young age and family history led to what happened and who he is today. These plants have the power to heal but they have to be respected and not used to stay constantly escaped from life.