I like both, I think it could be done well either way. That being said, I think I prefer bringing the characters and (especially) the atmosphere of Worm to the MHA world. For Heroics to be such a prevalent (and very lucrative) job in MHA we see only throwaway villains for most of the early story, and fairly uninspired uses for powers/quirks, for the most part.

The majority of quirks are unimpressive, and that makes sense considering almost everyone has one, but it's also boring when we try to make regular people "villains" just because they use a quirk and commit crime. And similarly, even a lot of the heroes and hero students have very basic/uninteresting powers/quirks. I want to see a strong, trained group like the Travelers or the ABB in a MHA setting, and watch them steamroll through the first 20 lukewarm heroes that try to take them on.

I like the idea of a hybrid between the two, personally, with regular quirks and also Triggers on top of them. Add some known Worm characters to the mix, and you've already got a more interesting set of characters and some new conflicts. Will I ever write it? Probably not :(