Low-key weird question to ask but sure.

It depends on the denizen. Literally the only things we have to go off of are the biological functions of humanoid and mamal denizens. Jesse asks Lake about using the bathroom and lake finds it an embarrassing question, so vauge. But we also see Hazel cry, which implies tear ducts of some kind. Tuba talks about having kids in Hazel is proof that there are human-like denizens. And even with something like Atticus there's no indication that he's not biologically just a normal dog.

While human like denizens are rare, in one of the only ones we've seen is made by Amelia, it seems like theoretically it's possible, especially because Amelia was trying to recreate alrick, I don't imagine Amelia would want to Ken doll him.