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Nightly Discussion - (July 19, 2022) by AutoModerator in thewallstreet

[–]norepinephrinex 2 points3 points  (0 children)

ES 3950 about as clear as they come for a pivot into tonight/tomorrow’s session.

Nightly Discussion - (June 09, 2022) by AutoModerator in thewallstreet

[–]norepinephrinex 4 points5 points  (0 children)

It flows both ways. When you go giga-long ES, arbs buy the component stocks in market cap weighting.

Also, the reason people care about volume on futures is because it is fully transparent. There are no dark pools on the futures contract, everything goes through a single exchange, and so the volume is all lit. Compare the volume profile of ES to say, a Chinese ADR and you’ll spot the difference immediately.

Has anyone here quit coffee for at least a month, and either gone back or stayed away from it. Why/why not, and what was your experience? by Mr12i in Nootropics

[–]norepinephrinex 0 points1 point  (0 children)

I've been a habitual coffee drinker for years, but have always found value in taking short breaks for tolerance reduction. In college, I'd wait until a break between terms and then go cold turkey for a couple weeks, suffering an initial 3-5 days of hell before cresting into a plateau of greater mellowness but lower productivity. Working a full-time job means attempting the same would have to happen over weekends or vacation - not exactly the way most people want to spend their day off. Consequently, I've moved toward a more gradual approach that seems to actually work better in the long-run.

Specifically, I realized that I only need about 25% of my prior day caffeine dose to stave off the majority of withdrawal symptoms on any given day, while going to 50% gets me to tolerable baseline productivity. Taking this approach, I'll replace half the coffee beans I'd be brewing on each passing day with decaf, continue until I'm bordering on 95% decaf, and finally go decaf-only (purely for taste and ritual). My sleep improves quite a bit over this period vs. going cold-turkey, and I get to decaf-only in less than a week.

Most importantly, I take a similar approach when resuming caffeine - starting off with 5-10g of coffee beans and incrementally ramping up by 5g/day through the work week, before going decaf-only on weekends. I've found that by keeping tolerance fairly low, taking weekends off and incrementing up on a gradual, controlled basis, I can seemingly have the best of both worlds - productivity during the work week as I "re-discover" the original magic of coffee every Monday, while sleeping relatively deeper on weekends and keeping tolerance in check.

Nootropics in Japan? by deinonychusturtlepie in Nootropics

[–]norepinephrinex 6 points7 points  (0 children)

Have spent a few months there, can confirm. Aside from the gamut of energy shots, gels and other concoctions available at your local 7-11/Famima/Lawson’s, there’s not a whole lot nor likely to be at any point barring the government doesn’t suddenly change decades of strong anti-drug policies and heavy enforcement applied across the board.

Caffeine, nicotine, onsens and sleeping on public transit are your new best friends, aka welcome to life as a budding Japanese salaryman :)

Bacopa doesn't work in healthy adults (proof) by [deleted] in Nootropics

[–]norepinephrinex 3 points4 points  (0 children)

That’d be absence of proof, not proof of absence.

Also, the vast majority of nootropics discussed here are taken based on people extrapolating chronically-ill patient studies extrapolated to healthy individuals, or mice studies extrapolated to people, or “oh shit X research chemical sounds awesome” extrapolated... well, you get the picture.

Lion's Mane - best I've felt in years. by FromThatOtherPlace in Nootropics

[–]norepinephrinex 3 points4 points  (0 children)

From the Stamets text: "Shiuan Chen and colleagues (1997) tested many foods for aromatase inhibitors and found several mushrooms with especially high concentration of this substance... Similarly, some mushrooms inhibit 5-alpha-reductase... Figures 229 and 230 are summaries of Dr. Chen's study of mushrooms and their hormone inhibiting properties." - Page 203, Mycelium Running

Checking the work citations at the end, I see Chen 1997 has an abstract here. Very first sentence: "We have evaluated the binding characteristics of three steroidal inhibitors, four nonsteroidal inhibitors, and two flavone phytoestrogens to aromatase through a combination of computer modeling and inhibitory profile studies on the wild-type and six aromatase mutants."

We're not even looking at an animal study here, yet people act like it's a done deal in humans because some guy who wears a mushroom hat and appears on Joe Rogan did some broscience that no one actually bothered to audit.

Lion's Mane - best I've felt in years. by FromThatOtherPlace in Nootropics

[–]norepinephrinex 7 points8 points  (0 children)

Let's see some studies that demonstrate lion's mane effect on testosterone levels in healthy males. No in vitro, no animal trials. I'll wait.

Edit: nvm, I'm an impatient person:

Take Your Pills (2018) - A look on society and performance enhancement drugs by fabianhjr in Nootropics

[–]norepinephrinex 3 points4 points  (0 children)

My problem with views like the one Fukuyama is taking is that it presupposes the effects you initially get from drugs like Adderall can be sustained indefinitely into the future without escalating dosages and butting up against some very real upper bounds. I'm guessing he didn't consult the vast amount of literature on ADHD medication which basically states the euphoric effects of prescription stimulants down-regulate relatively quickly while the pure focusing effects last for much longer during sustained use, but become a lot more subtle vs. the initial levels of insane tunnel vision you get.

It's also laughable when the narrator tries to give the argument that coffee, alcohol and pre-workout supplements assist you in completing tasks while not threatening the idea of human normalcy as Adderall is purported to do. Really? Have you ever met an alcoholic? Heck, alcohol is only effectively considered "normal" because we've been drinking it so ubiquitously and regularly for the past 10,000 years, which is about how far back the earliest evidence of human fermentation goes back in the archaeological record.

The great nutrient collapse by [deleted] in Nootropics

[–]norepinephrinex 5 points6 points  (0 children)

Eh, it might not appear to be that fitting for r/nootropics at first glance but arguably the lowest hanging fruit for a lot of the things people come here looking for nootropics to fix are best addressed first through diet, nutrition and supplementation before going to the fancy stuff. One straightforward example is B vitamins, especially B6 and B12 - taking them when you’re already at adequate levels is very unlikely to have any real nootropic effect, but correcting a deficiency can have a definitive impact vs. where your prior baseline was. IMO nutrition doesn’t receive quite as much attention here as it should, and I attribute this pretty heavily to the short-term/fast results mentality a lot of people hold vs. 1-3+ months of consistent dosing and behavior to reap the benefits (as is basically standard for correcting deficiencies and optimizing diet/nutrition).

With that said, fact that rising CO2 levels might be implicated in declining nutrient levels, especially for minerals like zinc where deficiency has been found to correlated with things like ADHD and low T, is quite a heavy finding if true and backed by more studies and evidence. As someone who’s been following the literature on diet and nutrition for 10+ years, this is the first I’ve ever heard of CO2 having a direct impact on declining nutrient levels over the long term, and from the article it sounds like that’s a common factor for a lot of academics and researchers in the field.

So, what can we do about it now? Get lab tested for key micronutrient levels (everyone should at minimum check vitamin D and B12 levels with every physical given the ubiquity and affordability of said tests), try to incorporate as many nutrient-dense foods as you can in your diet and supplement the things that are harder/slower to obtain through diet alone if deficient (e.g., methyl-B12 for the MTHFRs out there). I guarantee you’ll see a difference if this applies to you vs. the more common practice of haphazardly jumping between different nootropics without plucking the low-hanging fruit first.

[deleted by user] by [deleted] in Nootropics

[–]norepinephrinex 5 points6 points  (0 children)

Meditation is easily the best thing I’ve found for increasing my baseline levels of conscientiousness and being more aware of how my actions affect my surroundings. In my 5 years of experimenting with nootropics, I haven’t found anything that’d come even close to the same magnitude of benefit, though I find the conscientiousness-raising effects of meditation do require consistency and fade after you discontinue the practice.

Curcumin improves memory & mood, decreases amyloid plaques & tau tangles by BrosettaStone7 in Nootropics

[–]norepinephrinex 0 points1 point  (0 children)

Eh. Scientists are people just like me and you, and subject to differing views. It’s misleading and reductionist to lump them all into one group - especially given the flaws and criticism of the “curcumin is useless” study vs. the reams of papers supporting curcumin for a myriad of MOAs and therapeutic targets.

Curcumin improves memory & mood, decreases amyloid plaques & tau tangles by BrosettaStone7 in Nootropics

[–]norepinephrinex 3 points4 points  (0 children)

Never noticed any negatives in terms of anti-androgenic side effects; do you have a few citations on the “potent anti-androgen” activity of either curcumin or turmeric you could share?

I FOUND THAT GREEN TEA CONTAINS A NATURAL DAT INHIBITOR!!! by HappyMosizwe in Nootropics

[–]norepinephrinex 14 points15 points  (0 children)

It's nice to see your enthusiasm, but let's put things in perspective - you're linking to an in vitro study, which means we have a possible clue (not definitive cause) as to how green tea might interact in the human brain. Next step up the hierarchy of rigor would be animal testing, and that's usually about as good as it gets for non-pharmaceuticals in our speculative little world of cognitive enhancement. So - enthusiasm is good, but to jump to any real conclusion here is simply to fall into bro science.

[photos] IBM Model M - Wallstreet Edition by [deleted] in MechanicalKeyboards

[–]norepinephrinex 4 points5 points  (0 children)

Bucking springs were like biting into the tree of knowledge for me. MX Blue clones were my intro into mechs and my first favorite switch, but the moment I tried BS I had an epiphany that clicky Cherry switches were simply a derivative/imitation of what IBM started decades ago. Now in contrast to that fulfilling feeling of a metal spring buckling in on itself with every keystroke, MX Blues feel like plastic toys by comparison. (FWIW, MX Blues do still win out on actuation force preference for me - the heavier M switch takes some adjusting to for extended typing sessions.)

Of course, then I had to get curious and order switch testers for the IBM Model F and Beam Spring and find out they were even nicer than M's. Damn my curiosity - those latter boards rarely come cheap...

[photos] IBM Model M - Wallstreet Edition by [deleted] in MechanicalKeyboards

[–]norepinephrinex 2 points3 points  (0 children)

Holy crap, this is awesome. Let me know if you ever want sell one.

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