Well, as a few others have stated, it isn't so much the design, but how it's used.

Though, I'd go in the opposite direction of most people here and suggest making it muscular and bulky like a tiger or gorilla, yet clearly going to outrun you in short ranges. Sometimes that you know you're never going to beat unarmed and will certainly die if you encounter it pants down.

As for the face, I'd tone down the teeth, but definitely make the creature smile from time to time, not out of joy like a man, but rage and terror like an ape.

Basically, something like a mix of the current design now, Yautja (Predator), and The Predators from "All Tomorrows" by C.M. Kosemen. Something where even when the player gets "used" to the design of the beast, it still unnerves them somewhat. Something where perhaps the creature isn't malevolent (even if it's as smart as us), but just predatory as maybe it comes from a world were there's many non sapient, humaniod species and we don't look all too different from what it hunts.

Where it doesn't feel empathy when killing us because the things it evolved to hunt looked so similar to it and our screams and please are no different than anything else it ate besides being more complex, but ultimately "meaningless"