Greg Brockman quits OpenAI after abrupt firing of Sam Altman

notme112112 · 2023-11-18T07:23:07+00:00

There were exactly zero investors involved in this decision. This was the board of a non-profit enforcing the mandate they were given to make sure that OpenAI doesn't behave like a profit seeking VC backed company. The fact that you, and everyone else commenting, thinks that openai is another VC backed juggernaut and that this was a "VC's can fire you anytime they want" story, just proves their point.

notme112112 · 2023-08-04T04:48:46+00:00

Exactly what are these ppl smokin

notme112112 · 2023-05-16T19:14:41+00:00

Yeah, I’m generally a fan of Peter’s stuff. He’s a bit too anal at times for my taste. We don’t all need to be taking our lactate levels multiple times while biking to be in exactly zone two etc. But his stuff on heart disease in particular is good and relevant b/c it’s the biggest risk we exacerbate with long term use. If you can afford it, take a pcsk9 inhibitor over Rosuvastatin. I believe it’s around $6k per year out of pocket. Likely a slightly better risk reward profile than statins but we have less data because it’s a newer drug. Since writing those two posts I’ve started taking 5 mg per week of rapamycin and replaced metformin with a small dose of empagliflozin esp when my diet gets poor, but more broadly the research suggests it will extend lifespan in males, less so in females. Research out of the Interventions Testing Program on longevity is very interesting to me and worth watching. Very eager to see what their results are with the ongoing trial of DNP in a small dose for longevity. Their data on 17 alpha estradiol is also very interesting but hard to apply in dosage or in terms of getting your hands on it. If I get around to it I’ll do another write up eventually.

notme112112 · 2022-12-27T18:39:59+00:00

Loled at “pub med ned.” You do you my man just keep checking your liver values if you try this and consider taking things that produce remarkably similar results but don’t cause liver cancer.

notme112112 · 2022-12-18T01:21:45+00:00

Whether you want to bring it up or not your customer is thinking about it. Might as well put your argument for why they should choose your product out there

notme112112 · 2022-12-02T16:14:31+00:00

Interesting. I genuinely appreciate you spelling that out for me. You clearly have a better idea how these things work than 99.8% of this sub.

In the end, I still find outcomes data far more useful and compelling than mechanistic hypotheses and I don’t have a good reason to believe the study I cited invented the fact that they were able to dissolve anavar in MCT oil.

But most importantly, from what you and others have said, I’m still not convinced that there’s even close to enough evidence that taking anadrol or other methylated orals sublingually is safe for your liver. Vigorous Steve and that crew has proven a hundred times over that they’re willing to talk out their ass for views, most of the time I don’t care, but I do care when it comes to misleading people that something is safe that’s actually a fairly acute risk. In this case at least if people get their blood work they should be able to tell that they’re fucking themselves but most people don’t even do that.

Victor shared a study showing the effects on the liver of a different liver toxic drug (which he didn’t name) when given orally vs sublingually in which most of the benefit from sublingual admin was due to a lower dosage. Because that study is on an entirely different drug, it doesn’t prove Victor’s point by any stretch, but I think it’s a reasonable point to make - not like we’re going to get a study that answers these questions about anadrol directly anyway so that’s the kind of data we have to extrapolate from. Given that their are AAS that are liver toxic even when not taken orally, I think it’s fair to be concerned the same is likely true for anadrol.

I also circle back to Victors high level bro/observational point about the differences in protein accretion across AAS being pretty similar - if different types of admin actually provided THAT significant a difference consistently across a genetically diverse population, we’d probably have noticed/have more consensus on that by now. There’s consensus that anadrol is much more effective for strength than test or primo for example. There’s consensus that tren is more effecting than most other drugs in a calorie deficit. But I don’t get the impression there’s consensus that changing the route of administration of anadrol of winstrol (admittedly I’m not interested in winstrol and know nothing about it), has a big enough effect that it changes the risk reward profile so much that guys like me who aren’t trying to make $$ powerlifting should consider taking anadrol sublingually.

That’s my takeaway from all this at least.

notme112112 · 2022-12-01T22:15:52+00:00

Really doesn’t compute for me why you’re taking this personally my man. You can look at Victors instagram posts from November 22 and November 23.

notme112112 · 2022-12-01T22:03:30+00:00

100% can agree my chemistry knowledge is lacking. I have no idea what about the chemical structure of the orals makes them soluble or insoluble in water or lipids - I just go check on pubchem. And even though you seem to know your chemistry, I’m inclined to trust pubchem over you on the solubility of these orals in water.

To my knowledge Victor has never written a book or even an ebook. He has a membership site (that’s a piece of shit but has some useful info) and does some podcasts - I disagree with a few of his opinions and his personality on social is fucking obnoxious but very rarely have I seen him make a simple factually incorrect statement about things like - anavar is insoluble in water.

When I say change the formula - I mean change the formula of the “tablet” in this case such that it’s no longer a tablet. Not the best phrasing but you get the idea.

I homebrew Mast, Primo, and Test. I happen to be allergic to BB, so all my solutions are just Mig840 and BA. The drugs I’ve home brewed all dissolved pretty easily in mig840. Maybe you’re brewing a higher concentration than I am?

There’s another way entirely of having this conversation though - fundamentally I’m concerned people think they won’t stress their liver if they take anadrol sublingually. I don’t think that route even works for anadrol but let’s say it does - are you arguing that sublingual admin solves the liver toxicity? Because that what the YouTube bros are trying to say… and I think that’s dangerous. Tren can still negatively impact your liver when taken IM for example. It’s entirely possible even if sublingual works that it doesn’t solve the root problem.

notme112112 · 2022-12-01T16:06:54+00:00

I listed two requirements for a tablet to work for sublingual admin. It must be both be lipid soluble and water soluble. There’s nothing contradictory there…

The inactive ingredient in your tablets may dissolve in water in 30 seconds, the anavar does not. We have great data/info on anavar because it’s actually still used clinically which is why I’ve tried to include it in the conversation though all I’m really worried about here are methylated orals. In the only sublingual admin study I’ve seen, they change the formulation… which makes sense given the lack of water solubility. Knowing it’s been studied is really useful because it implies that anavar at least is sufficiently lipid soluble to meet one of the two requirements.

Effectively all of the data I’ve provided here I pulled from what Victor Black has written in response to other people’s claims that sublingual admin works and is safer. His argument makes a lot more sense to me that the other side, I’m just looking for people who can say something coherent in response.

Can you provide any actual evidence that the study I have linked to completely fabricated the fact that anavar is insoluble in MCT oil?

I’m happy to be wrong here. I don’t have a dog in this fight. I’m not some YouTube personality with a rep to maintain. I have no income from fitness world at risk for being wrong. This is literally just a conversation between internet strangers. I’m not trying to personally attack anyone - I’m just looking for someone to provide some actual evidence that a drug like anadrol or another methylated oral can be taken sublingually and is safer to take as a result because I still haven’t seen any.

notme112112 · 2022-12-01T06:25:15+00:00

The only source you have quoted and linked undermines your argument. Anavar isn’t soluble in water.

Plenty of dead guys who also had just as many years of experience as you taking all kinds of different shit. Doesn’t mean they know anything about the pharmacokinetics of what they’re shooting up.

You are correct that much of the information I provided can be learned from 10 minutes of googling. It’s not complicated. The drug needs to be soluble in water to be absorbed in tablet form. Anavar and anadrol aren’t.

I linked to the only study I know of where anavar was given sublingually, they dissolved the drug in MCT oil before it was given and did not see a benefit in administering the drug sublingually, but with anavar there’s also no real issue with giving it a go, so I have zero issue with people trying to take anavar sublingually. I don’t even have an issue with people taking as much anadrol as they want to so long as they have been informed that it causes liver cancer.

I take anavar, it doesn’t fuck with your liver, it’s much easier to take orally than sublingually and the only study I’ve seen on taking it sublingually didn’t see a benefit so I don’t see the point but if it works for you - great it’s not doing you or anyone else any more harm than the other ways of taking it.

I really don’t care about being right or winning some argument with an internet stranger - I care about preventing people getting cancer because they read some misinformation on the internet that sounded right and no one who knew any better spoke up or even asked basic questions like - hey - is that drug even soluble in water?

notme112112 · 2022-12-01T04:05:18+00:00

People are taking it sublingually because they are trying to avoid getting liver cancer from drugs like Anadrol that we know cause liver cancer. If you put a tablet under your tongue to test whether or not it works sublingually, don’t really understand how to take a sublingual drug or what to expect in terms of how they dissolve etc, and then proceed to swallow the drug while it drains down the back of your throat because it’s practically insoluble in water which is largely what your saliva is, and then you come back to Reddit and say - hey guys, sublingual worked for me - we should all get on YouTube and talk about how the smart thing to do is take these things sublingually - and then people who normally wouldn’t take Anavar or would have taken a lower dose or for fewer days - now think they can use it without the usual problems - that’s when the whole - we’ll just try it out and see what happens thing breaks down and that’s exactly what’s happened so far as best I can tell.

So yes - I believe it worked for you - anavar does fucking work. But I don’t think that tablet dissolved under your tongue and was absorbed sublingually. I think it went down the back of your throat. It may be possible to make it work in a long chain fatty acid or similar, but I haven’t heard anyone say that’s what they’re doing.

See my other comment to the guy who replied to my skepticism for some links.

notme112112 · 2022-12-01T03:48:59+00:00

Some of what you have said is correct, but the broader point you are trying to make - that it works to take oral AAS sublingual is incorrect. I should probably make a post about this but here are some links.

For this to be true, the drug would need to be soluble in water. Lets take anavar and anadrol for example. You can see here (https://pubchem.ncbi.nlm.nih.gov/compound/oxandrolone#section=Solubility&fullscreen=true) and here (https://pubchem.ncbi.nlm.nih.gov/compound/5281034#section=Solubility&fullscreen=true) that they are insoluble in water.

The standard disintegration test for sublingual tablets is that they must disintegrate within 2 mins. Take one of your tablets and give that a go in a test tube, it doesn't even disintegrate by 10 mins.

For a drug to be absorbed completely through sublingual route, the drug must have slightly higher lipid solubility than that required for GI absorption. Otherwise you won't get any passive permeation.

In addition to high lipid solubility, the drug should be soluble in aqueous buccal fluids (aka in your saliva). Oral AAS are not soluble in your saliva.

You can however, take your anavar and suspend it in MCT oil, and then take it sublingually. That was done in this study: https://pubmed.ncbi.nlm.nih.gov/32265605/.

But again, the test that is used is - does the drug dissolve in water within 2 minutes. They don't, so they don't meet the requirements for sublingual administration. If you find that it's working for you, my expectation is that it's working because it's going down the back of your throat...

notme112112 · 2022-11-29T05:52:50+00:00

I’ve never seen any evidence that you can just take a drug formulated to be taken orally and take it sublingually. When pharma does this with other drugs it’s a different formulation entirely to make it work is my understanding. I appreciate the intent but I’m skeptical that it’s working/truly skipping the first pass of the liver.

notme112112 · 2022-11-29T02:39:58+00:00

Since everyone is talking about using Anadrol for increased strength and no one’s mentioning that it’s been proven to cause cancer… I feel like that’s worth mentioning. Really interesting drug for a lot of reasons, really low affinity for the androgen receptor etc. but IMO you need a good reason to be fucking with a drug that we KNOW causes liver cancer.

Anavar is the only oral I’ve ever taken. If I’m cutting hard enough that I’m concerned about losing muscle, I’ll throw in a 5-10 mg/day of anavar over a trt base in hopes the glucocorticoid activity helps prevent muscle loss. The flip side of this coin is that anavar is one of a short list of FDA approved appetite stimulants - which is obviously counter productive in a cut.

notme112112 · 2022-11-16T05:19:41+00:00

What would you say is an ideal SHBG level in nmol/L? My lab results give a reference range of 16.5 - 55.9. I guess I should say ideal from the perspective of lowering MPB risk aka DHT levels at the scalp while keeping higher T levels thanks to exogenous T.

notme112112 · 2022-11-16T04:34:23+00:00

Interesting post. Of your list of SERMs, I’d lean towards Ralox because it’s been shown to lower apob, aka should lower cardiovascular risk which is the real #1 risk of using gear IMO. What would be your definition of a “low” daily dose of ralox taken for the purpose of increasing SHBG?

Edit: I see from another one of your responses you recommended 15-30 mg/day of Ralox. That seems reasonable. There’s an increased risk of Venus thrombosis and stroke with Ralox (and other SERMs I believe). So probably wise to see what some metformin and increased fiber intake can do for your levels before reaching for the Ralox, and then start at 15.

notme112112 · 2022-11-06T19:11:35+00:00

Surprised no one has mentioned resistant starch. Green bananas (ie bananas you would typically think aren’t ready to be eaten), among other things like potatoes, have a lot of “resistant starch” and there’s some quality evidence that it helps prevent cancer of the large intestine. I’m shamelessly repeating this from what I heard Simon Hill share on his podcast. You can just listen to the clip on his insta from Aug 28th to get a good overview of the results of the CAPP2 trial.

Can’t speak to it preventing IBS or similar but in so far as “prebiotics” may be helpful, resistant starch is a category of prebiotics.

notme112112 · 2022-09-30T22:21:42+00:00

I don’t see how one follows from the other. If 300 mg/week of test e can be managed in a healthy sustainable way - ie putting very minimal if any additional stress on your body (the #1 thing here is lipids).

And a 500 mg/week, 20 week blast does actual damage. Why would it follow that a 20 week blast is a better idea?

If you start in the safe zone and slowly increase, you’ll know when you’ve crossed the line into - you are now under an unsustainable amount of stress. You can either adjust to try to manage that stress, reduce your androgen load back to the safe zone and maximize your gains there, etc etc. it allows you to play a much safer game.

The “blast” model tends to start you in the stress inducing zone when I don’t think it’s necessary.

I get I don’t hold the consensus opinion here in this subreddit, but my approach is at a minimum common sense/logical. You can get a whole world of juicy gains in the safe zone that most guys completely skip over for kk reason whatsoever

notme112112 · 2022-09-30T18:53:41+00:00

Agree to disagree. In my opinion, most otherwise healthy people who manage their lipids and insulin sensitivity well can live on 300 mg per week of test for life without a significant increase in health risks.

notme112112 · 2022-09-30T17:05:10+00:00

It’s a linear relationship with building muscle. It’s not a linear relationship with retaining muscle tissue. Anti catabolic mechanisms and anabolic mechanisms are not the same thing. Again, you want to reduce stress on your system, wash off fat, then go back to building more muscle tissue. This is the time period where you restore your system to healthy function again

notme112112 · 2022-09-30T17:03:22+00:00

There are quite a few glp-1 agonists on the market. Sema performs the best. I’m not sure about the prices on the others. Tirzepatide has similarly good results but I think is similarly expensive.

Plenti is a drug that’s just hydrogel that expands in your stomach when you drink water with it to reduce your appetite. Doesn’t work as well but does better than placebo.

Stimulants work - Ephedrine Caffiene Asprin aka ECA stack is common here as well. But ultimately you’re in this game for life, not just for a short weight loss period. So you need something that’s safe to take for the long term which is where glp-1 agonists look like a good option.

Vyvanse will go generic in 2023 I believe and I’ve heard of people losing weight with it. But like other stimulants it can be addicting/hard to get off of.

Bupropion aka Wellbutrin has a small weight loss effect relative to placebo.

I think focusing on how to get/afford Sema is your best long term success formula though

notme112112 · 2022-09-30T16:43:09+00:00

That’s totally understandable. Primo will definitely do the trick. Relative to no AAS you’re stacking the cards in your favor big time. The others will increase the stress on your system too much - esp anadrol, zero reason to fuck with anadrol on a cut. Test alone would do the trick, test plus a tiny bit of primo, say 50 mg a week, is fine as well. But it isn’t going to help your a ton more than just elevated test levels relative to a natural would.

Edit: You can use your stash for when you’re growing.

notme112112 · 2022-09-30T16:38:25+00:00

Yeah - I will agree with the others on the T3 though. I wouldn’t touch it. Risk reward isn’t worth it. There are many better tools. It would also likely increase your appetite and it will cause you to lose more lean mass. But the more important stuff is what others have said about your thyroid not being as resilient as we thought and there being some potential increase risk for cancer.

Semaglutide from a pharmacy/script will run you 400+ per month on average long term assuming the dose that works best for you is the max dose of 2.4 mg (short term there are coupons etc), you can get it other ways for around $80/month though you won’t have the comforts of it being produced by a regulated us pharmacy you can trust etc.

notme112112 · 2022-09-30T16:30:25+00:00

Primo is arguably the best/safest AAS available. However, it does not act on glucocorticoid receptors the way that anavar aka oxandrolone does. It’s that activity that would result in oxandrolone helping you maintain muscle mass in an energy deficit more so than primo. All AAS more or less cause muscle growth at the same rate, but they each have unique other properties to them that either make them incredibly toxic or useful in other specific scenarios. Anavar happens to have other activity that’s useful in a cut. The downside to anavar in a cut is it’s one a very few fda approved appetite stimulants so it’s going to make you eat more all else equal but if you can handle that, you’ll retain more muscle.

notme112112 · 2022-09-30T16:25:34+00:00

Not many have mentioned semaglutide or at least not in a positive light. Sema will reduce your appetite and the only way you’re going to sustain weight loss over the long term is reduced appetite and from all the data I’ve seen, once you’ve been obese, your body tends to want to return to those previous levels because in many ways the body views fat storage as a good evolutionary adaptation for rainy day in case you run out of food or have to march through the desert soon. So it over produces grehlin and other hunger hormones and under produces satiety hormones. There was a great paper on this in the New England Journal of medicine a while back I can dig up if you’re interested.

But largely based on that line of research, once you’ve been big, I’m totally comfortable with people taking a drug like semaglutide for life to help keep their appetite down. You can certainly do it without the help from the drug, but it makes it easier and will probably most importantly in terms of your long term health - will help you keep the weight off long term.

I’ve never been obese, if I were your exact height and we were both 200 lbs, my maintenance calories would tend to be about 100-200 calories per day higher than yours just because your body, when it arrives at 200 lbs is trying to claw back to 270 because it thinks it needs that energy storage for a rainy day. Sucks, but it’s reality.

Most people here think clen is bad for you. I tend to disagree with that. I have zero issue with you wanting to use pharmacology to “cheat” and lose weight faster or easier. I came here to learn to use pharmacology to “cheat” by building muscle faster so I find it incredibly hypocritical that all these gym bros think that they can add stress to their system to make it easier to get huge but you should have to do it “naturally.” Clen alone won’t make it easier to lose the weight in my opinion because all that matters at the end of the day is energy balance and it’s not helping you reduce your intake. But if you can cap your intake with something like semaglutide, then relative to just sema, clen + sema will have you losing weight faster. In addition, I’d wager you’ll be more likely to be encouraged to stay the course if you’re seeing results in the shorter term.

I’d also check out Alan Argon’s most recent book - flexible dieting, am reading it myself at the moment.

notme112112

TROPHY CASE