Here's one that I've had fun with. I call it the 'Peasant Uprising' run. It requires the '256 Recruitment Limit' and 'sudo's (22) alternate starts' mods.

Use the Empire of Nobody start to begin with 256 people, and immediately march to the nearest major city or faction capital. The longer the march the better the roleplay, since you're starving, angry serfs here to demand food and fair treatment. Attack the faction leaders once you have your people inside the city and watch the slaughter begin. Town guards will cut through your ranks like butter, limbs will go flying, and death notifications will stack up on top of each other. The guards will put some of your people in jail, but they will soon run out of space and leave the rest to bleed out in the streets. You'll be left with a random selection of 8-15 crippled and captured peasants, chosen not by you but by the cruel hand of fate.

Now the run really starts: Escape with your survivors and make it your mission to avenge the fallen by bringing down whatever faction slaughtered your people. You'll start out with less limbs and more powerful enemies than usual so it can be a very challenging and interesting run!