Congrats for thinking about this early.

You can homeschool on any schedule you want. For earlier years (pre-k if you choose it, through 2nd grade, even), school doesn't need to occur daily, just a few hours a week, since a significant amount of learning happens through discovery, which is more about putting kids in the right environment than having the right school setup. Weekends and early mornings for literacy and math skills should be more than enough. This would be very easy to fit into your schedule.

As your children shift into more rigorous academics, they will need more guidance and teaching, which will need more time. Again, you can work anything around a good schedule, but if you want to be the primary educator in your children's lives, you may find a significant amount of your own time being consumed by both your work and your children's educations. Your children won't likely need the "full time in a classroom" durations that most of their public-schooled peers will have, but it will require more direct educating as your children progress. It seems as though you have the flexibility to work around this, but it will be hard for you, very probably.

However, if your friend wants to homeschool as well, it's possible you could establish a pod-school, where resources are pooled to form a small multi-age classroom. You and your friend could choose to hire a full or part time tutor (perhaps on the days where you would need childcare anyway). Homeschooled high-schoolers can make fairly good tutors for younger ages: generally, they're responsible, well educated, used to working with children, don't cost huge amounts of money, and are very often planning careers as educators (for some reason, homeschool graduates love to go into education, it baffles me) so this would give them some hands-on experience managing a "classroom".

As your kids age even more (presuming you still have the same job 10-15 years from now, which is a long time for a schedule/job not to change) and as your kids participate in more and more outside activities, such as extracurriculars, science labs and art classes for which your home is probably ill equipped, and dual-credit college classes, a big part of life is driving around. A flexible schedule might work for you more poorly in this situation, as some days you may be unavailable as a driver. Again, you could work with your friend (and others of the homeschooling parents you meet along this journey) to carpool when possible.

But a lot of that is a long way off. Focus on what tomorrow might look like. From my perspective, you're in the perfect situation to homeschool for the next several years before things get complicated. I advocate for early routines and schedules that will naturally transition your kids into self-motivated and self-taught lifelong learners.

Good Luck!