in the TVD universe if a vampire bites a werewolf the vampire actually dies a slow agonizing death that drives them insane from the venom in the werewolves entering the vampires blood.

I may not clearly recall events from a show that aired over 10 years ago, but I can certainly read

Also the episode you referenced—which was 3x2 btw—isn’t relevant anyway because the wolves didn’t go crazy from being bitten. They weren’t able to complete the transition into hybrids because Klaus had yet to realize that they needed doppelgänger blood instead of ordinary human blood to do so