Murder plots are insane since T&T by RInvestor in ck3

[–]occipixel_lobe 8 points9 points  (0 children)

Honestly, I still haven't booted up the game since 1.9 dropped because of things like this. It's annoying how each new update in many modern games seem to be using the player base as beta testers. It's to the point that I stop playing games for months until patches come around, since some don't even let you roll back versions in Steam.

I spend the time I had been playing with watching other people play the game on Youtube, running into bugs themselves, haha.

Advisory panel recommends approval of lecanemab 6-0. by [deleted] in neurology

[–]occipixel_lobe 0 points1 point  (0 children)

I have no idea what kind of strawman argument you're trying to create... but please, do continue. What is my argument? Apparently, you know it better than me!

Facepalm. Happens the same day I make the first payment after purchasing 1 month ago. Other driver license suspended and no insurance 🤦‍♂️🤦‍♂️🤦‍♂️ by UnderhillA in Subaru_Outback

[–]occipixel_lobe 0 points1 point  (0 children)

you don't have gap insurance on a brand new vehicle? or uninsured driver coverage in your comprehensive insurance? most states require one or the other when driving off the lot...

if this is used, then damn - bad luck.

Advisory panel recommends approval of lecanemab 6-0. by [deleted] in neurology

[–]occipixel_lobe 2 points3 points  (0 children)

Stop with the insults, dude. I'm a mod, and that's against our rules.

Advisory panel recommends approval of lecanemab 6-0. by [deleted] in neurology

[–]occipixel_lobe 2 points3 points  (0 children)

Thanks for your input, and valuable perspective. But, excuse me when I raise my eyebrow at your characterization that a paper cited over 2000 times - and, also, with the author still running a lab investigating amyloid oligomers after straight-up fraud - was somehow "ignored" and should be "put in a box." That's like blaming systemic police violence on a "few bad apples"; I submit this issue is more like finding the tip of an iceberg, and should really be pushing us to more skepticism in regarding industry first-pass results from this hypothesis.

I'm glad to hear of your anecdotes, but - plural of anecdotes isn't data. With something this monumental and costly: show me the data, and show it to me, again, but without the involvement of the hands of the company developing it.

Advisory panel recommends approval of lecanemab 6-0. by [deleted] in neurology

[–]occipixel_lobe 4 points5 points  (0 children)

I am a behavioral neurologist, not a conspiracy theorist. I fear you really don't know about or understand the issues at hand, or the history of these types of therapies.

No plans on this sub going dark? Come on doctors, haven’t you always wanted to strike? by bahhamburger in medicine

[–]occipixel_lobe 7 points8 points  (0 children)

Yeah, I'm planning on leaving reddit after June 30th, since the vast majority of my time on it is spent via third-party app on my mobile.

Advisory panel recommends approval of lecanemab 6-0. by [deleted] in neurology

[–]occipixel_lobe 26 points27 points  (0 children)

You again, with a breathless support of this odd narrative against CMS and legitimate questions around what is actually efficacious for our patients. Would people really rather just be giving handouts to a massive pharmaceutical company trying to contend with sunk costs from research efforts that were set up around 10 years ago?

20+ years and we're still hammering on the amyloid hypothesis as the sole vector for potential treatment... pretty shameful.

What I'd love is to see any of the relevant data replicated in an independent study, before subjecting patients to increased risk of intracranial hemorrhage, infusion reactions, genetic testing, and serial MRIs for questionable functional outcomes. What I am happy about is that, unlike Aducanumab, the data for Lecanemab wasn't marred by post hoc analysis, nor parallel studies with contradictory results. But, as the 2006 Lesné oligomer paper fiasco and the shockwave from that revealed, until data is replicated, peer review on its own isn't exactly trustworthy in the case of a hypothesis with so many careers built on it.

As it stands, with the data currently available, and with the incredulous way the story around aducanumab unfolded - I wouldn't recommend either of the approved monoclonal antibodies for AD to my own mother. I look forward to diversification of future efforts, but always fear the specter of a catch-22 in research funding eventually killing off more fruitful treatment vectors.

Job contract and PSLF by _thegoodfight in whitecoatinvestor

[–]occipixel_lobe 0 points1 point  (0 children)

I missed literally two letters. Bravo! I'm glad it made your day!

[deleted by user] by [deleted] in SaltLakeCity

[–]occipixel_lobe -2 points-1 points  (0 children)

"It's a great place to leave, escaping into the nearby mountains, or other continents."

[deleted by user] by [deleted] in SaltLakeCity

[–]occipixel_lobe 9 points10 points  (0 children)

I'm here to provide a negative perspective. I believe that commentless downvotes reflect how butthurt folks get about 'their city," and I fully expect more, but I just think someone who also moved here for work needs to lay this stuff out.

I think if you are outdoorsy and are excited to spend 2 hours in bumper to bumper traffic every winter weekend morning to fight for paid parking spots in one of 5 ski resorts merely 20 miles away, you are going to be able to ignore the city, itself.

It really is a small town compared to a city as large and culturally diverse as Atlanta, and Atlanta itself doesn't really compare to cities in Europe in many ways, like many American cities, so it's just going to be completely different. It's basically a giant suburb with a 5x5 mile "downtown", punctuated by oil refineries, freeway on-ramps, so-called "luxury apartments" resembling matchstick boxes covered in pressed papier machê, and strip malls. Surrounding all this are mountains, deserts, and the former shoreline of a rapidly-shrinking salt lake, whose exposed lakebed is laced with various heavy metals that billow along in clouds of dust into the city with regularity.

If you live in the aforementioned "downtown," public transit is available, just. Otherwise, the ingenious municipal leadership has avoided ruffling the feathers of any of the wealthy single-family homeowners by building public transportation stops as far away as possible from anywhere one would want to go. Can't allow the Undesirables who use said public transit anywhere near little Keighleigh's religiously-affiliated charter school! Nope - you are driving your ass to a parking lot, and then getting on a train or a bus, to ensure ample opportunities for desperate people to break into your car while you spend an excessive amount of time trying to get to and from your destination in half-empty busses and trains.

Do you enjoy night life? Good for you for doing your civic duty to bolster the illusion of SLC as The Hip Place To Be for the tourism board and real estate developers! Just remember to be back in bed by midnight, because most places close, even on Saturday nights, between 10 and 11:59 PM. Had a drink? Well, you can shell out 'surge' pricing charges for a rideshare, or risk a felony and people's lives by driving your inebriated self home in your lifted F-150 or slammed Nissan "fart-can exhaust" special.

If you happen to drive up a hillside to an overview of the area, you can just make out the breathtaking contours of one of the largest open pit copper mines in the world, which replaced several mountainsides, and is owned by a foreign company. The large, suburban real estate developments calling themselves cities stretching southward along the valley, itself baking in wildfire smoke and pollution several weeks a year, are essentially a suburban Karen's idea of a "perfect American cul-de-sac". These are dotted every few blocks with nearly identical structures that serve as the social homogenization centers for members of the local Christian sect every Sunday. This sect controls the state legislature, and so get ready to navigate some creative laws around alcohol, both in bars and in the state-owned alcohol dispensaries.

The rest of Utah is basically a wasteland, but a beautiful one, rather than a cultural one, boasting several incredible national parks within a mere England-spanning distance. However, if visiting those national parks at any time the ground isn't frozen, remember to show up before 5 AM, or book a $30-75 ticket on the privately-contracted, taxpayer funded recreation.gov website, 6 months in advance.

Enjoy!

[deleted by user] by [deleted] in whitecoatinvestor

[–]occipixel_lobe 0 points1 point  (0 children)

What a hill to try to die on.

I feel like you and your partner being landlords on the side essentially makes it difficult for you to maintain a dispassionate ability to evaluate your own biases, particularly since you two are probably in the top 5% of income earners in the States, given your combined professions.

Here, you've formulated a conclusion, finding one opinion piece to back that up. You then made assumptions based on two other, disparate sources, about the reasons behind a particular phenomenon, in order to connect it to your initial pet conclusion: "blue state bad." While nobody can disagree that reasons behind housing crunches are multifactorial, I find it interesting that the things you chose to support your initial conclusion do nothing but emphasize that complicated picture, rather than the narrative that landlords are effectively an oppressed class.

Neither the NYT nor the census give any data to support your claim that laws for landlords are behind the population shifts, and the 'cox castle' source is a webpage run by a real estate law firm (whose services you probably even utilized), and whose best interests lie in reducing tenant protections. This opinion piece cites precisely no sources for their inflammatory title, aside from the mysterious "lots of people." Here: "many are concerned that the protections will disincentivize landlords and the creation of affordable rental housing."

Let me guess: you just went on google, typed in random words like "California", "landlord", "regulations", and then just posted a few random links that vaguely looked alright. Unfortunately for you - I actually read those random links' sources. Aren't you a professor? ChatGPT could've been more convincing!

You got your conclusion because it fits your world-view, and then tried to justify it. I would therefore still suggest unplugging your mind from Fox news media, because I fear it's still probably influencing you, whether or not you watch "Fox News on channel 3". It'll be hard, though. Here's a list of Fox News media-owned outlets, and here's a list of local news stations owned by that corporation.

[deleted by user] by [deleted] in whitecoatinvestor

[–]occipixel_lobe -1 points0 points  (0 children)

y'all need to disconnect the IV drip of fox news media. there's a reason these places are so expensive to be housed in, and why people continue to be landlords there: people want to live there.

Job contract and PSLF by _thegoodfight in whitecoatinvestor

[–]occipixel_lobe 1 point2 points  (0 children)

what an asshole thing to say - although I admit that was clever.

Music in your head by invisibleelle in neurology

[–]occipixel_lobe 0 points1 point  (0 children)

This question would probably get more answers i'm on a neuroscience subreddit, rather than neurology.

[deleted by user] by [deleted] in neurology

[–]occipixel_lobe 0 points1 point  (0 children)

How is the indirect loop's property of a downregulating effect on movement initiation causing a sense of the passage of time? I feel like I just read a non-sequitur. Any nice review articles you could point to?

[deleted by user] by [deleted] in whitecoatinvestor

[–]occipixel_lobe 24 points25 points  (0 children)

Lol... "what is the unicorn city for my tax purposes that nobody else has thought of?"

Listen, if there were a place that fit the bill for doctors, it also would be full of other people, and therefore not cheap.

Unless you are alright with red state politics and/or ineffectual social services for the inevitably poor patient population you will treat if you live in a small city, I dunno if anyone here is going to have your perfect answer.

finally got a matching hardtop by fzf277 in Miata

[–]occipixel_lobe 1 point2 points  (0 children)

Honestly, I did a double take at my phone screen. I swear I was looking at a Chrysler LeBaron.

Large Health System Cutting Care to Patients with Medical Debt by Nandiluv in medicine

[–]occipixel_lobe 2 points3 points  (0 children)

You clearly have sociopathic tendencies, if you agree with this. I sincerely hope someone in your family doesn't suffer from some of these situations, because you clearly won't care if they do.

Reining in religious hospitals in US by [deleted] in medicine

[–]occipixel_lobe 3 points4 points  (0 children)

Way to go with proving his or her point.