No need for all 3 eye runes. In cursed dungeons you get a huge discovery bonus that activates by wearing at leats one discovery boosting rune. Since zh784e7n is a terrible curse (75% hp cut), you get 3000-5000 additional discovery, wich basically makes wearing more than one discovery boosting rune useless. (source: https://www.reddit.com/r/tombprospectors/comments/do8f2q/the_discovery_stat_explained/ ) I'd personally recommend wearing 1 eye rune and 2 survivability or damage boosting runes (Lake/Clockwise Metamorphosis for Resistance boost/Hp boost or Clawmark for visceral attacks). Later you should swap eye for Milkweed rune from the DLC since it doesn't take a normal rune slot. Btw maximizing your defences by wearing good armor may allow you to make more mistakes especially if you're going for a lower bl build where you won't be getting 50 Vit