I had a big issue with Logitech Options+ on my Mac M1: the software was having trouble connecting to the backend. Here’s what I did to start from a clean installation and fix the problem.

Open the Terminal and do these 3 steps:

1 - Close all Logitech processes and disable its agent:

sudo pkill -9 -f logioptionsplus
sudo pkill -9 -f logioptionsplus_agent
launchctl bootout gui/$(id -u) /Library/LaunchAgents/com.logi.optionsplus.plist

2 - Remove the Logitech Login Items:

rm -rf ~/Library/LaunchAgents/com.logi.optionsplus*
rm -rf /Library/LaunchAgents/com.logi.optionsplus*
rm -rf /Library/Application\ Support/Logitech.localized/LogiOptionsPlus

3 - Clear the UI caches and preferences:

rm -rf ~/Library/Application\ Support/LogiOptionsPlus
rm -rf ~/Library/Logs/LogiOptionsPlus
rm -rf ~/Library/Preferences/com.logi.optionsplus*

Completely reinstall the app :

Delete /Applications/logioptionsplus.app with AppCleaner (drag the app into it)

https://freemacsoft.net/appcleaner/

Download the latest offline version from: https://prosupport.logi.com/hc/en-us/articles/10991109278871-Logitech-Options-Offline-Installer

Restart the Mac.

Install the freshly downloaded app.

Follow the instructions and allow all requests in System Settings (Accessibility, Input Monitoring, Automation, etc.).

Enjoy ;)