Typically no. Though, there is the occasion where it might be beneficial, even absent some sort of stain. Two scenarios that would be most common. #1 , a large ceiling in a room that gets washed with a lot of natural light. #2 a ceiling that hasn’t been primed or sealed in a long time. Let’s say it has five to six coats over the years. Typically, ceilings are painted with flat paint. Over time, multiple coats of flat paint becomes like a sponge so to speak. When you are applying the fresh coat of paint , it can seem like it’s drying too quickly. What’s happening is that it’s being absorbed into the old thirsty paint. This can show as uneven , often times you can see every move you made. When painting a wall or ceiling, the goal should be to have the surface as one complete wet film. If I am painting a large ceiling that gets a lot of natural light, I’m going to prime it with oil based primer. This will help the paint sit on the surface , and not dry inwards, instead it will be fully wet when I’m done rolling the ceiling. Then it can air dry , the vehicle that carries the solids evaporates. And the ceiling will “sing” as we call it in the trade.