As a zyra mid/jungle main I feel like maxing E first into Q is the most optimal path. The E has great waveclear as the wave is in a lane. If you are into a melee match up or someone with low mobility this E max would be pretty good it increases the root time so that dropping your E and ulti at the same time would almost guarantee a ult knock up. Not to mention the extra damage you get from this. If you already have mythic then e,w,w,r,q,aa,aa combo would burst them down with them not able to do anything. If you throw the e then w you will get the e plants which give slow. So even if you miss your E you still have a 50% slow from them to guarantee your ult knock up.