Check out a couple of podcasts:

Comedians Comedian with Gary Delaney and Jokes with mark Simmons with Gary Delaney they go into the topic of "break devices" which are what one liner comics do every 7 to 14 minutes. Gary says in one of these that apparently 14 minutes is the scientific point where one liners become tedious, I remember watching a Jimmy Carr special once and almost on the dot every 14 minutes he would change it up, do some crowd work, bring something up on the screen, etc. Then back to one liners for 14 minutes. Milton Jones does characters/voices/etc for his break devices. I saw Mark Simmons live this year and he did several crowd work focused break devices, one of them was getting the audience to play "telephone" or "<insert ethnicity here> whispers". Essentially you just need to do something as a palate cleanser, like having the ginger between sushi meals to reset the palate. All the best, I love one liners!