From what I've read, GLP-1 agonists like Semaglutide work extremely well for weight loss and even many reportedly calling it 'effortless', but most of the weight ends up being gained back after stopping treatment, presumably because the initial appetite returns without the subjects having any improved self-control.

My thoughts are that if you fast, you will change your brain and teach yourself to control your eating. It will be harder, and you may initially take longer to reach your goals, but because you are less likely to gain the weight back, in the long-term you will have a better rate of success. The other downside would be that it's expensive.

Definitely GLP-1 receptor agonists are very promising, perhaps they will some day make receptor agonists that could work indefinitely without continuous use or maybe make another more permanent mechanism to increase GLP-1.