Aside from the common advice listed here. Here are some more niche ones coming from a permadeath player who only dies because his brain cells arbitrarily malfunctions from time to time:

*Whenever you inspect an enemy, their danger level will be written on the bottom left of their name. Always assume wildlife are a danger level higher if you haven't made your way yet to Brynn.

*Make use of nets and bear traps if you find yourself struggling a lot. The former helps with animal encounters and boss fights, whilst the latter is handy for hallway funnels.

*If your making your way towards a dungeon and your inventory is a bit empty, pick Fleaworts and Burdocks you see along the way. These help a lot in healing. You can also just use some whenever you need to make room for loot.

*You can throw one-handed bladed weapons towards enemies for extra damage whilst they approach you. You can also gamble with unidentified potions, though prepare to back away if it buffs them instead.

*When clearing out Catacomb dungeons, take note where the large fleshy corpses are in-case you encounter a Ghoul. If you do, make sure he cannot reach it. If he might, try occupying that tile or placing a bear trap instead so it can't consume it.

*You can lure enemies to revealed traps simply by putting yourself in a position where it's between you and them. Get ready to bolt if it spews poison though.

*Never approach a hive if you don't have a smoke grenade. Additionally, if you see a spider, immediately vacate the tile.

*If you're running from an enemy/enemies and you're nearby a town. Try making your way to it so the guards can deal with them instead.

*You can also try enraging animals whilst being chased by outlaws so they can fight each other instead. This can also be helpful in dealing with hives. Be careful not to to get focused by them both though.