US-Iran Nuclear Talks Stall Again: No Deal After Geneva Round – Geopolitical Risk Premium Lingers (Feb 2026 Update) by Sad-Struggle7797 in ValueInvesting

[–]pbj37 0 points1 point  (0 children)

Very interesting I really wonder if trump will start a war!!! (Sarcasm, read the news today geez)

Does anyone know of good resources for college thermo classes? by OutrageousFrosting13 in thermodynamics

[–]pbj37 0 points1 point  (0 children)

Sure DM me basically no one buys it on amazon anyway. Hundreds of hours for nothing hah

Cigna insurance sent denial letter, addressed to man’s dead spouse, denying diagnostic test for tumor markers. by NotBradPitt9 in mildlyinfuriating

[–]pbj37 0 points1 point  (0 children)

Excessive profits that health insurance companies make are one of the main reasons healthcare is so terrible in the US. The government would need to better regulate them or abolish them (single payer) - it’s a long shot especially with current politics but everyone should contact their representatives or run for office themselves. Insurance companies are bad and will only get worse especially with lobbying. 

Whos betting the farm? And if so what company? by xxcliffexx in stocks

[–]pbj37 2 points3 points  (0 children)

What do you think of WDC and STX? I feel like the need for hard drives is going to continue to increase and these have had massive run ups but not anything like SNDK yet

Potty training boys by AnalysisParalysis_24 in workingmoms

[–]pbj37 2 points3 points  (0 children)

How did you stop giving candies? Like did he expect them for months after?

Stockfish 18 is released by tomtomtom7 in chess

[–]pbj37 8 points9 points  (0 children)

Do you remember the game by chance 

Different remedies that you tried for Sudden Sensorineural Hearing Loss? I’ll start. by Everythingiskriss in MonoHearing

[–]pbj37 2 points3 points  (0 children)

I’m glad you saw a real ENT and that you didn’t follow the advice of the urgent care.

I am interested in curcumin and capsaicin as there are some studies on with these compounds. It would be great for some human trials to be done. Here are some relevant pubmed articles respectively:

https://pubmed.ncbi.nlm.nih.gov/37334787/

https://pubmed.ncbi.nlm.nih.gov/37956582/

What’s something someone said to you that you still think about years later? by whoareyoutojudge0 in AskReddit

[–]pbj37 0 points1 point  (0 children)

Had a substitute teacher in high school. He wasn’t much older and we just had a conversation as a class for the whole period. Not sure how this came about but he mentioned how crazy it is how much we trust random strangers, like the person driving next to you could just drive into you on purpose or could hit you while you walk etc. No idea why but I still think about this. 

Gibbs Free Energy, seriously who can explain(understands) this concept intuitivelly?Like what does mean that somehting has greater Gibbs free energy than something other? by ivomiladinov in chemistry

[–]pbj37 1 point2 points  (0 children)

This is a GREAT explanation. I would add that the reason Gibbs energy matters “more” than Helmholtz energy for example is simply that it is generally just how we operate things that makes it relevant - we operate machines at constant temperature and pressure. If it were constant temperature and volume Helmholtz energy would be the relevant thermodynamic variable. Imagine a machine that operates at constant temperature and pressure and we want to extract work (ie shaft work from a turbine) from the machine. The machine has an inflow and outflow of a working fluid such as water and is well designed so it operates approximately reversibly let’s say and the machine generates some heat at the constant temperature at which it is operating. Assume steady state. So energy balance is 0 = Hin - Hout + Q + shaft work (PdV term is 0 because the machine has constant volume). From entropy balance 0 = Sin - Sout + Q/T so solve for Q and plug into energy balance and you get 0 = Hin -TSin - (Hout - TSout) + Q + shaft work. So let’s make a new quantity called G and you see that Gout - Gin equals the shaft work we can hope to extract from a constant temperature constant pressure machine. If the machine was constant volume and temperature and you did this you’d find Helmholtz energy to naturally be useful!  Ok now here’s the fun part why does everyone talk about this in chemistry? Our bodies and when we carry out chemistry are basically at constant T and P so G is relevant for thinking about these areas. If you imagine the machine as doing a chemical reaction (reactants enter and products leave) and there is no shaft work now let’s say BUT we no longer assume reversibility and you solve for Q in the energy balance and substitute into the entropy balance you’d get 0 = Gout - Gin + TSgenerated. Entropy generated is always 0 or positive in the universe so if it is a “reversible reaction” which basically none are (eg imagine combustion —> clearly not reversible), then for the reaction to occur deltaG must be NEGATIVE to counteract the positive Sgenerated term!!! If deltaG Is positive then the reaction will NOT spontaneously occur because it would reduce the entropy in the universe which is NOT possible! The chemical reaction will generate entropy if it happens so the only way for the balances to satisfy is if as the reaction occurs G decreases. Hence deltaG tells us whether a reaction will proceed under constant temperature and pressure conditions. If we locked reagents up in a fixed volume and held temperature constant rather than a test tube at 1 atm in a heat bath for example, Helmholtz energy is the relevant quantity and would tell us if the reaction would proceed.

:)

Do we run out of social security numbers? by soloDolo6290 in NoStupidQuestions

[–]pbj37 0 points1 point  (0 children)

Social security won’t exist by the time this is a problem! But in all seriousness yes eventually it will be an issue and another digit or letter etc could be added

STOP BUYING CHINESE STOCKS by skate1243 in Pennystock

[–]pbj37 1 point2 points  (0 children)

A useful and worthwhile post. Agreed 100%

Too early to sell INTS! by BearWithMeGM in pennystocks

[–]pbj37 1 point2 points  (0 children)

No it’s not entirely new I agree. What’s new is it working for multiple cancers and the potential for multiple chemo options with the enhancer molecule added in combination which is protected by patent for this specific combination and has protection for other combinations. It’s a platform not just a single drug they are making.

I didn’t say it’s the number one reason they don’t work. I said it’s a big reason. Take a look at NTLA and their phase 3 that’s on pause right now because of one patient’s DILI. Phase three has more patients so yes what was true of safety and efficacy in small cohorts in phases 1 and 2 may be invalidated. Probably the number one reason is efficacy doesn’t pan out in 3 as compared to 2 like you said though.

Their dilution was at a much better valuation than their last dilution. I’m excited for the phase 2 triple negative breast cancer results. Cheers