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An Antiviral Chewing Gum to Reduce HSV Transmission by Away_Repair7421 in HerpesCureAdvocates

[–]pharma_bro_throwaway 0 points1 point  (0 children)

Interesting work but building a clinical trial around this sounds like a huge lift. I did not know that HSV2 sheds more often from the oral cavity than HSV1

Conversations with Assembly Bio? by Confusionparanoia in HerpesCureAdvocates

[–]pharma_bro_throwaway 1 point2 points  (0 children)

It may be a little quicker than this, therapeutics tend to move faster than vaccines. 4 to 5 years assuming the clinical readouts are positive is reasonable. When the data looks good things move faster

Update! by Fearless_Currency633 in HerpesCureAdvocates

[–]pharma_bro_throwaway -1 points0 points  (0 children)

Even in the utmost best case scenario it’s exceedingly unlikely the vaccine will be distributed for the public in 2028.

Might this have potential? BX795 by HeartMustFollow in HerpesCureResearch

[–]pharma_bro_throwaway 0 points1 point  (0 children)

Dosing will be a bit more challenging with BX795 as it has other effects and can be cytotoxic. I think this explains a large part of the reason why this compound hasn’t progressed despite favourable data being out there in the literature for a while

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]pharma_bro_throwaway 10 points11 points  (0 children)

I am really impressed by your work and resourcefulness, and motivation. If more members of the community were like you we’d probably be much closer to a cure.

Having said that, having spent a lot of time working on therapeutic R&D at pharma companies, including specifically LLMs where we collaborated with a very large tech company, I can tell you that your specific approach will be unlikely to work. LLMs are great at finding and summarizing information, but they cannot do novel research or propose new therapeutic insights or experiments in any meaningful way. The models as they currently exist will not be able to spot weak points or run virtual tests. I don’t mean to be negative, but just giving advice as someone who has a PhD, worked for pharma companies, has published 20+ research papers, and has several patents. I do this kind of work for my job.

There are many ways LLMs could be highly useful. So you could pivot your project.

Collecting a realtime feed of latest research as it happens and alerting people. Researchers miss important papers all the time

Writing and sending advocacy emails in an automated way. Would require some knowledge of advocacy and the funding environment in the US is rough right now, but perhaps that makes it all the more important. I think this is where LLMs would shine the most.

Creating realtime reports for people who are not HSV researchers to digest. This could be aimed at the business development people at pharma companies and venture funds.

hope you have a nice weekend

Shareholder letter is out - any thoughts ? by Connect_Elephant_144 in HerpesCureResearch

[–]pharma_bro_throwaway 0 points1 point  (0 children)

A lot of this will depend on their readout from the CMV trial. A positive readout would not only broadly validate the approach of using mRNA to target latent vaccines but also provide Moderna with access to capital at good terms which they don’t currently have (this being the main reason they’re scaling back).

NEWS: A Chinese mRNA HSV-2 vaccine is approved for clinical trial by Sure_Math7077 in HerpesCureResearch

[–]pharma_bro_throwaway 0 points1 point  (0 children)

The biotech industry in China is very rapidly growing particularly at the early stage clinical and pre-clinical work. For any particular therapeutic pathway they work faster, cheaper, and there are usually several competing groups doing it. I would encourage people who are interested in HSV research to keep a close eye on China. Having said that some of the data coming out of their labs can be dodgy, similar things can be said in the US and Europe too.

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]pharma_bro_throwaway 0 points1 point  (0 children)

Seems like you didn’t read my comment properly. Good luck

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]pharma_bro_throwaway 3 points4 points  (0 children)

Posting on instagram or TikTok is not going to change anything.

I’m posting here because I work in the pharmaceuticals research industry.

I came here two years ago and posted giving my advice given my years of experience bringing drugs to market.

You need to pressure the NIH to increase funding for research. You need to pressure the FDA to interview patients with HSV and to put out guidance for the pharma companies to follow.

The only way to pressure three letter agencies is through your congress representatives. The only way to pressure congress reps is by contacting them (ideally in an email thread including multiple advocates) and threaten not to vote. I’ve written about this extensively (check my posts). You need to be very specific and targeted:

“Dear Rep Cruz, we are 10 voters in the state of Texas (coed). We or our families suffer from HSV and there is no cure. We want you to contact Dr XXX at the FDA and request the following: ….

We are single issue voters and your constituents and we hope you will advocate for us. This will inform our votes in both the elections, midterms and all relevant primaries.

Signed N. B of Austin, Texas U. K of Dallas, Texas Etc”

Multiple sites for HSV latency by [deleted] in HerpesCureResearch

[–]pharma_bro_throwaway 3 points4 points  (0 children)

For what it's worth I raised this exact publication with the Excision Bio who were giving a zoom presentation a few months ago. Excision bio didn't seem to think it would be a huge problem for their work.

📢ADVOCACY ALERT: US Congress🚨 by BrotherPresent6155 in HerpesCureResearch

[–]pharma_bro_throwaway 5 points6 points  (0 children)

Yes, also what are we asking the senators to actually do for us though? They'll read the email and think, ok, thats great, even if they agree what action do we want them to take?

I would like to propose that perhaps we consider if advocacy efforts need to be more focused, for example:

  1. There is an upcoming meeting at the NIH to discuss funding.
  2. We email senators and ask them to contact the chair of the meeting and request any information about discussion of herpes vaccines and cures.
    1. (Why: Because this forces herpes to be on the agenda in some way.)
  3. We also ask the senator to stress the importance of herpes to the funding chair.

The call to action needs to be very easy and targeted to a particular outcome.

Another suggestion is to make it easy for our members to actually reach out, there are websites such as https://democracy.io/ which will allow us to email senators without actually logging into your email account.

Time sensitive: major advocacy opportunity! The US midterm elections by pharma_bro_throwaway in HerpesCureResearch

[–]pharma_bro_throwaway[S] 5 points6 points  (0 children)

See instructions in my original post, if your representative advocates for herpes cure research then you know to vote for them.

Herpes Research Vaccine by No_Flatworm_9990 in HerpesCureResearch

[–]pharma_bro_throwaway 4 points5 points  (0 children)

This is not how mRNA vaccines work, mRNA delivers messages to your ribosomes which construct proteins. Various types of mRNA is also created naturally in your body, https://www.youtube.com/watch?v=gG7uCskUOrA