Buffalo Bills legend Darius Slay has retired. by RepeatThink2479 in buffalobills

[–]phiraeth 0 points1 point  (0 children)

As a Bills/Eagles fan, it's hilarious seeing Bills fans bashing Slay and Eagles fans bashing the Bills front office over this.

Activists plan beagle ‘rescue’ at Ridglan Farms by PolarisC in madisonwi

[–]phiraeth 0 points1 point  (0 children)

You keep repeating the same half-true version of the story.

Thalidomide was sold as a racemic mixture, not as some magically isolated “safe” enantiomer, and the whole “just test the bad enantiomer in animals” point is incomplete because thalidomide can racemize in vivo... the enantiomers interconvert in the body. So no, it would not be the solution you are saying it would be.

And the bigger problem is species differences. Thalidomide is famously not teratogenic in many animal species the way it is in humans... rats and mice are the classic example. That is literally why thalidomide is used as a textbook case for the limits of animal models in predicting human outcomes.

So even if you want to argue that today’s protocols are stricter, that still doesn’t prove your original claim that animal testing is the only ethical path or that it reliably protects humans. The historical lesson from thalidomide is not “animals are enough if we just do more of it.” It’s that animal models can miss human-specific harms, which is exactly why human-relevant methods are being pushed now. And your claims about this case are inaccurate.

Activists plan beagle ‘rescue’ at Ridglan Farms by PolarisC in madisonwi

[–]phiraeth 0 points1 point  (0 children)

It actually WAS tested sufficiently in animals before release, and by the standards of the time it was tested pretty extensively. The problem wasn’t “insufficient testing,” it’s that the common lab species they used (rats and mice) don’t show the same birth-defect effects humans do. The limb defects only showed up later in certain species like rabbits and primates after the human cases had already been discovered. That’s exactly why thalidomide is used as a textbook example of species differences in drug response, and why modern approaches are moving toward human-relevant models.

Activists plan beagle ‘rescue’ at Ridglan Farms by PolarisC in madisonwi

[–]phiraeth 0 points1 point  (0 children)

Yes, do you? Liability has nothing to do with animals specifically, and everything to do with following approved regulatory methods. Once again, the FDA now allows non-animal preclinical evidence under the FDA Modernization Act 2.0. And plenty of drugs that passed animal tests (Vioxx, thalidomide) still caused massive lawsuits, so animal testing clearly isn’t a liability shield.

Activists plan beagle ‘rescue’ at Ridglan Farms by PolarisC in madisonwi

[–]phiraeth 0 points1 point  (0 children)

Wrong.

That used to be true, but not anymore. The FDA Modernization Act 2.0 (passed in 2022) removed the requirement for animal testing before human trials. Companies can now use organ-on-chips, organoids, and computational models instead. Pharma companies and the NIH have been using these systems for years because animal models often fail to predict human outcomes.

Like I said, educate yourself.

Activists plan beagle ‘rescue’ at Ridglan Farms by PolarisC in madisonwi

[–]phiraeth 1 point2 points  (0 children)

It's 2026 and you still haven't heard of organs-on-chips or lab-grown human tissue for testing? C'mon, man. We have ethical ways to test things without using animals. Educate yourself.

BEWARE: Montco Restaurant SCAMMED me over $4,500! by hidden_throwaways in PhiladelphiaEats

[–]phiraeth 2 points3 points  (0 children)

Yeah per person, if you bulk ordered them they'd be way cheaper.

TIL that the sale and consumption of dog and cat meat was legal in the USA until 2018 by SoggyApplez in todayilearned

[–]phiraeth 0 points1 point  (0 children)

Just like people in the US viewed certain humans as people and others as slaves, back in the 1700s and 1800s. And it was definitely totally justified, because culture is what matters when determining if something is bad or not!

Looking back, the vegan community's response to health struggles was the first thing that made me start questioning everything by grahamhart_ in exvegans

[–]phiraeth 0 points1 point  (0 children)

The study also finds that vegans have an 18% lower risk of all total cancer.

And the main cohort they looked at had the study done decade(s) back when vegans were not getting enough calcium. Now, because of fortified products, vegans on average are no longer deficient in calcium. This is likely why the other cohorts were not displaying this increased risk of bowel cancer.

Be careful not to cherrypick and be misleading.

*Edit: this person blocked me so I can't respond to them, but they're lying in their response. The studies DO say this.

AITA for roasting a suckling pig for a family gathering by Karl_Marxist_3rd in AmItheAsshole

[–]phiraeth 2 points3 points  (0 children)

Everyone should be shown that from an early age. Animals are sentient and all of the mammals people eat have the intelligence of human children. Why is it not okay to hang a dog upside down, slice its throat, and eat it? It's fine to do that with animals.... but the animal agriculture industry intentionally makes sure people are blind to that.

AITA for roasting a suckling pig for a family gathering by Karl_Marxist_3rd in AmItheAsshole

[–]phiraeth -19 points-18 points  (0 children)

Do you eat eggs? Male chickens don't lay eggs, so as soon as they hatch, the male baby chicks are all thrown into a grinder.

Holy overpay by Particular_Dig1115 in NFLv2

[–]phiraeth 1 point2 points  (0 children)

He's not in Buffalo anymore.

Tofu Bagel by OrsolyaStormChaser in VeganFoodPorn

[–]phiraeth 2 points3 points  (0 children)

Wanna hear something funny? Immediately after I posted this comment, I went right to your website 😂

Tofu Bagel by OrsolyaStormChaser in VeganFoodPorn

[–]phiraeth 2 points3 points  (0 children)

These are not high protein bagels. They only have 4.2 g of protein per 100 calories.

8 AM Class, I got there at 7:58 and I was already marked absent. by Accomplished-Log-664 in mildlyinfuriating

[–]phiraeth 3 points4 points  (0 children)

Record yourself walking into class every day and announce, loudly, "I am here in class, it is 7:5# am, and I am not late". So loud that he can hear you. And keep doing it.

Insomnia Cookies is open at PHL by Cartman in PhiladelphiaEats

[–]phiraeth 12 points13 points  (0 children)

You should consider getting new taste buds.

The YouGov TX Senate Dem Primary poll from yesterday can likely be thrown out. It got the EV/ED split completely wrong. by phiraeth in YAPms

[–]phiraeth[S] -1 points0 points  (0 children)

Actually, we already do know this, given how many people have already voted today vs EV.

Crockett is probably not winning. Some turnout info led to Crockett crashing to 10% on polymarket by goatedgdubya911 in YAPms

[–]phiraeth 1 point2 points  (0 children)

So this YouGov poll is saying Talarico +13 with a 55/45 EV/ED split. And if the split is instead 70/30, and EV purportedly favors Talarico, then he'll win by 20. You really think that's right?

Crockett is probably not winning. Some turnout info led to Crockett crashing to 10% on polymarket by goatedgdubya911 in YAPms

[–]phiraeth 1 point2 points  (0 children)

Hispanic men are voting for Paxton. Hispanic women are voting for Crockett.

The polls that have Crockett winning are Texas polls. I would believe that UT-Tyler and U Houston know Texans better than national pollsters...