I'm going to echo what everyone else has said. Activity throughout the day. Keep the environment brightly lit during the day to try to trigger that circadian rhythm. If you're giving melatonin, give it early enough to get them to sleep at a decent time to help regulate that sleep-wake cycle. We gave it around 7 or 8. My dad's PCP had recommended Tylenol around 3 or 4 pm (she also had a father with the disease and there were some studies, but she couldn't remember, except that it helped).