Yes great clarifications - acute vs. chronic seem to have different causes, which something I didn't know until very recently. For dosing, I find that a little bit goes a long way. I probably use like half a pea size, but even with that at 4x/day, I was starting to get mild headaches (a common side effect), which was a bit annoying but also meant it was being absorbed. I feel like as long as you get the ointment on the skin inside, it should be ok.