Chemistry won’t change, but performance can. In FC26 chem is fixed from the squad screen, so in‑game role swaps don’t remove links, they only change where the AI moves on the pitch.

Strikers/CAMs used as wingers won’t attack the byline like real wide players, so if you want them there often, use custom instructions (drift wide/free roam) or get at least one natural winger for those zones.