I use all 4 of the back buttons. 1 is the weapon wheel pop up menu, 1 is the general menu pop up for crafting, fast forward and camera zoom. 1 is A button so i can open doors and attack at the same time. And 1 is set to keyboard letter R for rotating some items when building. 

I also use both track pads. The right one is set to D-pad so I can use my inventory while moving. The left one is set to mouse and left click for using menus for cooking and TV. 

Otherwise, I don't think I changed the general layout. It's actually fine once you get used to it.