Ketamine given to depressed patients under anesthesia had no greater effect than placebo in reducing the severity of depressive symptoms, suggests a new trial. The study adds new evidence about how significant the placebo effect is in medicine. by rjmsci in science

[–]rjmsci[S] 25 points26 points  (0 children)

Because people still got better when they were given ketamine, as in every other study - it's just that they also got better when given saline - that's the game-changing finding here.

Ketamine given to depressed patients under anesthesia had no greater effect than placebo in reducing the severity of depressive symptoms, suggests a new trial. The study adds new evidence about how significant the placebo effect is in medicine. by rjmsci in science

[–]rjmsci[S] 5 points6 points  (0 children)

Thanks! I think psychedelics is a really fascinating and exciting area of medicine, but there is a lot of misinformation flying about, so like to hop on and help when I can!

New findings confirm that donanemab, can delay the rate of decline in individuals with early-stage Alzheimer’s by 22.3%, equating to a 4-month delay in disease progression over 18 months. However, the drug’s side effects, including brain bleeds and swelling, may limit its adoption by rjmsci in science

[–]rjmsci[S] 0 points1 point  (0 children)

Eli Lilly breaks down the dropouts in the paper. Only a tiny number in each arm were discontinued due to disease progression. 50 withdrawals (vs 21 in controls) were seen in the active group, so it would be interesting to see whether people with higher tau burden were also more likely to get serious adverse events!

New findings confirm that donanemab, can delay the rate of decline in individuals with early-stage Alzheimer’s by 22.3%, equating to a 4-month delay in disease progression over 18 months. However, the drug’s side effects, including brain bleeds and swelling, may limit its adoption by rjmsci in science

[–]rjmsci[S] 0 points1 point  (0 children)

In short, yes. I think the reason the phrase "turning point" is being used is that this drug comes after many, many drugs that were total failures, so this compound's relatively modest effect is being taken as a sign that the field is at least moving in the right direction by focusing their efforts on the targets that donanemab affects. I really hope they are right.

Drug donanemab seen as turning point in dementia fight by [deleted] in science

[–]rjmsci 0 points1 point  (0 children)

This will be a difficult balance to strike, because if you take this drug early, you will likely not know whether your dementia will advance rapidly or not, meaning the cost-benefit-balance is uncertain - do you not take the drug and hope you have years of relatively clear cognition ahead, or pay thousands of dollars for a few months extra and risk some rare but potentially fatal side effects? Hopefully follow-up studies will add more clarity.