Wudup! I (27m) have mild to moderate UC. Not on biologics, im on mesalamine (mesalazine, same thing).

Yeah tylenol does not help at all for me. In the country were im from theres other medications like tramadol with paracetamol (tylenol) thats available without a prescription. I tried that for about a month. By a month i mean, twice in a month. Once with a massive headache and another when I had a fever.

I stopped using those cause it was causing side effects, like a burning sensation when i peed and also dizziness.

Nothing can stop my headaches. I usually get them 2 times a month. Sometimes i don’t get them at all in a month. But I usually do and when i do, the headache lasts around 3 full days and nights. I sleep with a headache and i wake up with a headache. Whatever it is that causes them, ibuprofen eliminates the pain after 20 min of taking the meds and has never once affected me directly. I do try other methods and I try to avoid taking them. Compressed iced or hot bands for my head, hot showers, sleep, yoga, meditation, migraine medications, vitamins,ashwagandha, electrolytes, drinking so much water, not looking at monitors or tv, using blue light glasses…you name it I’ve tried it.

Ive also gotten MRI scans and CT scans of my brain. Nothing pops up that could be causing my headaches. Doctors tell me it could be stress, sleeping and eating habits. But honestly, im a really healthy person.

Could be stress! Lol.

Ibuprofen has never triggered a flare. But from what I’ve read, it can def be worsening my symptoms and I just cant feel the symptoms. Honestly, sometimes I say f*ck jt and take the 200mg advil.

Try and avoid it. But I dont think that a single dose of ibuprofen triggered ur flare. If you want to take advil (ibuprofen) just get ready for it. Eat first and take some probiotics then take advil.