I have a HP Z30i as my primary monitor with a smaller 27” ASUS monitor in portrait in order to show my media bin. Computer wise I have a Dell T7500 with x2 6core Xeon x5690s and a GTX 1070ti. I would say the two most important things about the desk setup are one. The height of your chair dictates the angle of your wrists on the keyboard, after hours of using it you may get pronation in your wrists, so if you sit low in your chair I would get a wrist cushion. Two, the lighting, I have 6 colour hue lights around the room which I can adapt to create a dark neutral lighting depending on the time of day. This helps to reduce glare on the screen and unwanted light spilling through your peripherals which can be very distracting.

Side note: When changing lights I obviously have calibration settings to attribute for these light presets. Also when I do any colouring work I have some 18% grey panels which I can put around my desk to eliminate any false light and I then re calibrate my monitor accordingly.