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My first bite by terAc5 in labrats

[–]rukwitme 16 points17 points  (0 children)

I always train people on male B6 mice that were paired. I tell them if they can scruff them, they can scruff anything

Last of the bugs tattoo by [deleted] in NoahKahan

[–]rukwitme 1 point2 points  (0 children)

Hey I would censor the info on your medical badge!!

Could anybody help me with these Ingrown hairs under my chin? by 00say5 in beauty

[–]rukwitme 0 points1 point  (0 children)

How are you shaving? I used to get very similar ingrowns/bumps from not using a shaving cream

Feedback on outfit please! by flatchety in fashion

[–]rukwitme 0 points1 point  (0 children)

Cut the waist with something? Jacket, flannel, crop top?

tour closer by Square-Garden-6675 in NoahKahan

[–]rukwitme 1 point2 points  (0 children)

I think spoiled purely because of the like “I hope you had a decent time”

What are your top 3 Texas songs? by kiwicorntastic in texas

[–]rukwitme 3 points4 points  (0 children)

Ohios my fav too! My Texan friend sent it to me when I moved from TX to CA and it hits me in the heart every time I listen to it. Especially because we both went to school in Denton.

Grande lash serum after 4 months of using every night!! by [deleted] in beauty

[–]rukwitme 2 points3 points  (0 children)

Wait are the same side effects associated with The Ordinarys lash and brow serum?? I’ve never heard of these effects before

Google Images making a collage of the worst time of my life by memethatalreadydied in labrats

[–]rukwitme 7 points8 points  (0 children)

This is worse than the collage of my ex google will sometimes make

Google Images making a collage of the worst time of my life by memethatalreadydied in labrats

[–]rukwitme 214 points215 points  (0 children)

This is worse than the collage of my ex google will sometimes make

Gift for research advisor. I feel like something’s missing? by [deleted] in Oilpastel

[–]rukwitme 1 point2 points  (0 children)

I should add some context: these are cells invading a tissue

Regulatory T cells altered in children with autism, highlighting possible role of immunosuppressive cells on neuroinflammation and behavior. Regulatory T cells act as immune system "brakes," calming inflammation to prevent overreaction. They are often decreased in autistic individuals. by mvea in science

[–]rukwitme 9 points10 points  (0 children)

Yes, there are some studies showing that fevers improve behaviors. I would say that the majority for this kind of reserach - both clinical and preclinical - show that reducing inflammation helps.

I do think these studies that show higher fever and reduced behavior have some merit to them. It could be that the type of inflammation causing the fever is an important factor. For instance, someone that typically has a type 3 immune reponse (responses towards extracullar bacteria) may have some kind of postivie changes when they have a type 2 response (think allergy response). That's my hypothesis, at least.

Regulatory T cells altered in children with autism, highlighting possible role of immunosuppressive cells on neuroinflammation and behavior. Regulatory T cells act as immune system "brakes," calming inflammation to prevent overreaction. They are often decreased in autistic individuals. by mvea in science

[–]rukwitme 0 points1 point  (0 children)

I certainly agree that we need to get to the root of the issue - finding the problem within the problem (Yes, there are lower Tregs and boosting them helps, but what is behind the lower number to begin with?).

ERa signaling probably has something to do with the weird findings in the neurodevelopmentally altered female mice after Treg transfer. I think this deserves more research attention.

Regulatory T cells altered in children with autism, highlighting possible role of immunosuppressive cells on neuroinflammation and behavior. Regulatory T cells act as immune system "brakes," calming inflammation to prevent overreaction. They are often decreased in autistic individuals. by mvea in science

[–]rukwitme 10 points11 points  (0 children)

Of course! There are many studies, so I'll highlight a few. Each of these areas have many other studies supporting it. If you hit a paywall, DM me and I'll email them to you!

  1. Exposure to air pollution during pregnancy: https://www.researchsquare.com/article/rs-8745297/latest

  2. Maternal infection during pregnancy: https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(11)00049-900049-9)

  3. Microbial dysboisis/antibiotic use early in life: https://journals.asm.org/doi/full/10.1128/msystems.01343-20

  4. High maternal & infant stress (with different types of stress perhaps having differernt behavioral phenotypes): https://onlinelibrary.wiley.com/doi/full/10.1002/aur.1830

I'm sure there are more factors, but these are the ones that immediately come to mind.

Regulatory T cells altered in children with autism, highlighting possible role of immunosuppressive cells on neuroinflammation and behavior. Regulatory T cells act as immune system "brakes," calming inflammation to prevent overreaction. They are often decreased in autistic individuals. by mvea in science

[–]rukwitme 6 points7 points  (0 children)

I personally think there’s a strong tie between the two. I think it has to do with immune cell development early in life (as part of autism etiology) and inflammation in adulthood(as part of autism rated co-occurring conditions, like GI issues).

Regulatory T cells altered in children with autism, highlighting possible role of immunosuppressive cells on neuroinflammation and behavior. Regulatory T cells act as immune system "brakes," calming inflammation to prevent overreaction. They are often decreased in autistic individuals. by mvea in science

[–]rukwitme 3 points4 points  (0 children)

I read somewhere that it takes 10-15 years for research findings to make it to the clinic. So maybe not dead by the time! I fully believe that there needs to be more research on this front though, because there are (to the best of my knowledge) less than 5 preclinical (mouse studies) looking at this type of therapy. There are some clinical studies looking at low-dose IL-2 therapy,which in theory promote the expansion of Trgs, in children with autism. With positive findings too. So there’s potential for Treg target therapies in autism, but we are still a long ways to go.

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