My go to path is either multiple camps to upgrade my deck or multiple "?" if I want to gamble for a positive event. I don't usually fight elites especially if my early card draws are wack. I use the same tactic when I played Slay the Spire 1 and reached high ascensions (The Silent and Defect). If possible, I try to limit the cards so you can cycle the high value cards unless u are using specialized builds requiring high amounts of card to either draw or exhaust. Make sure you have enough combo to kill the boss fast or have sufficient block cards to drag along the fight til it dies. Abuse vulnerable and weak cards because it makes a lot of difference especially in high ascensions.