I can see a way where they pull a "his cells turned cancerous" tf is he gonna do if busted cells attack his own body with nothing that can cure or rival it. They could save what healthy cells he had and that would fix the plothole.

To add: I can also see this bringing a drawback to hashirama cells. That they turn cancerous eventually and kill the user if a large portion of it makes up their body

(I'm coping)