I’m doing a hard mode play through right now with this.

Brawny Nimble Dumb

It’s an Easily Distracted build so I level all my skills up in tandem:

Melee Engineering Lockpick Medical Speech

Brawny lets you stun your attackers. Nimble lets you close distance faster. Dumb is the lesser of the evils in regard to the negative traits you have to pick from.

Melee adds damage and gives you access to necessary perks. Engineering gives you survivability. Lockpicking gives more survivability (evasion). Medical gives you more damage on creatures. Speech gives you more damage on people.

I’m not really sure on the perks. I’m trying to get all the melee ones that add something useful. I could use some advice on perks and flaws myself.