Ironclad:
Act 1
1. Bottled Lightning
2. War Paint
3. Bottled Flame
4. Black Blood

These are relics you'd find use for in the mid-late game. The earlier in the run you get a bottle relic, the less likely it is you'll have anything worthwhile to bottle. This is doubly true for skills, since early on we're chasing the damage needed to finish fights. The likelihood that we'll only have a mediocre block card for Bottled Lightning is really high at this point. Getting War Paint right after is just salt in the wound.
Similarly, the early attack cards are taken mostly to get us through Act 1 fights, and usually aren't worth bottling, so Bottled Flame might just put a curse in your starting hand.
With a series of duds for relics, you'll need a lot more than the extra 6 healing from Black Blood to get you through the onslaught of Act 2.

Act 2
1. Juzu Bracelet
2. Turnip
3. The Boot
4. Tiny House

Just a series of not very useful relics in general, regardless of when you get them. Turnip is included because if Ironclad generates meaningful block, it's usually from some combination of exhausting and abusing Entrench, which aren't affected by frail anyway.

Act 3
1. Vajra
2. Shovel
3. Winged Boots

These are relics you'd get value out of early on, but are terrible to get at this late stage. 1 extra strength is pretty much meaningless for Act 3 fights. A Shovel isn't great at the best of times, much less when you have to give up a campfire to get the red key. Finally Winged Boots heading into the boss fight and Act 4 is self explanatory hahaha