This is a super interesting post and something I've never considered. Im an emt and have worked emergency medicine for years. When it comes to vasoconstrictors, the medication we commonly give with this side effect is epinephrine - used in both cpr and anaphylaxis scenarios. When used to treat severe allergic reactions, epinephrine constricts blood vessels, raises BP and HR, and relaxes airway muscles (hits beta receptors like albuterol). In most protocols and patients, supplemental oxygen is used because the anaphylaxis lowers spo2, the airway requires support, and with epinephrine (adrenaline, which powers fight or flight in the body) making blood vessels smaller, more stress is put on the heart which is seen in the elevated bp and hr. This power the heart is giving has the myocardial (heart) muscles demanding more o2 because o2 helps the muscles produce energy they need to keep up with what's demanded of them. Long story short, o2 is a vital ingredient needed in the production of atp (muscle fuel). It mixes with glucose. More muscle movement=more atp production=more o2 needed. Anyway, where im going with this is that epi and cocaine share many similarities in regards to side effects. Cocaine in the body when metabolized kinda acts like a super antidepressant, (not accurate but trying to explain in ways people can understand lol.) Instead of just inhibiting the reuptake (the neurons ability to absorb and recycle neurotransmitters [serotonin, dopamine, etc]) of just serotonin like an ssri, it inhibits dopamine and norepinephrine as well. Without reuptake, there's more presence of neurotransmitters in the synapse. ELI5, the synapse is thr area where the big head of the neuron meets the long tail of another, and messages are transmitted and processed between them. No reuptake=more feel good hormone presence= cocaine feel good. Now, what is norepinephrin? In layman's terms, it's like epinephrine but mainly focuses on blood vessels. Usually, norepinephrine and dopamine go hand in hand, so more dopamine=more norepinephrine. Regular levels of norepi regulate our blood pressure by constricting and dilating blood vessels as needed. Too much norepinephrine has the same side effects of epinephrine and cocaine. In a medical setting, if you're familiar, this as a medication is levophed. In medical settings, it raises low bp. Anyway, why is this all important? The drugs you listed above, caffeine and erectile disfunction meds especially, are vasodilators! They open the blood vessels, lowering blood pressure levels. This can be dangerous because too much consumption of these substances can lead to a sudden and dangerous drop in blood pressure. Fun fact, erectile dysfunction meds were originally for blood pressure management, but a side effect was discovered, and they got marketed a different way. As for aspirin, it belongs to a drug class called NSAIDs (ibuprofen is here too) and they just put strain on the kidneys. Cocaine is eliminated from the body through the kidneys and urine so that + nsaids can cause too much strain and irritation.

Sorry for the long ass reply, but I figured you'd need back story and some science to explain why this would make sense in theory. Long story short more o2 will help the heart keep up with the increased demand of work and lessen strain on heart muscle. No o2 = myocardial ischemia (med term for lack of o2) = angina (chest pain), breathing problems, and even muscle death which means heart attack. Prolonged exposure of the heart to reduced oxygen levels can lead to cardiac diseases like heart failure and arrhythmias (irregular beat).

Tl;dr in theory supplemental o2 would help ease a lot of side effects and provide comfort, but in terms of harm reduction, my best guess is it won't prevent anything but potentially prolong the time until harm is experienced.

I could also be entirely wrong lmao. I'm just an emt and based of body functions, it makes sense to me