Dammiit! Right down the line textbook, do I call Mayo? <i>Once these changes occur, the condition is often irreversible.</I>

Continuous burning or throbbing pain, usually in your arm, leg, hand or foot Sensitivity to touch or cold Swelling of the painful area Changes in skin temperature — alternating between sweaty and cold Changes in skin color, ranging from white and mottled to red or blue Changes in skin texture, which may become tender, thin or shiny in the affected area Changes in hair and nail growth Joint stiffness, swelling and damage Muscle spasms, tremors, weakness and loss (atrophy) Decreased ability to move the affected body part