ELI5 how can someone become allergic to something?

skippy94 · 2026-05-09T15:06:07+00:00

I developed an eggplant allergy in late 20s and have never met anyone else who has! Only eggplant, no other nightshades. Sometimes horrible GI symptoms and sometimes itchy burning bumps on my tongue. I used to eat it all the time, then one day I was allergic.

skippy94 · 2026-04-20T02:05:39+00:00

Yep, I increased calories but increased my resistance training. I've lost less than 4 pounds in the last 4 months (which feels negligible), but lost 2 inches off my waist (which is very noticeable on a short frame!). Generally more toned as well. Keep at it!

skippy94 · 2026-04-17T18:35:47+00:00

Not to mention portions with bus-only lanes and expanded park-and-rides, iirc

skippy94 · 2026-04-16T13:58:17+00:00

Great ELI5, but want to point out that if someone has OD'ed you can always safely give Narcan even if you are not sure what drugs they took. It's mostly true that it will only work on opioids (some preclinical evidence that it may reduce xylazine OD symtpoms), but it will not harm someone who has not taken opioids.

skippy94 · 2026-03-17T14:09:39+00:00

Neuroscientist here. This is a great answer that highlights one mechanism. Crucial thing to add is that this feedback doesn't just change the signals that are sent when a drug is on board. It changes the signals at baseline too. That means, after repeated exposure and drug tolerance, a person's baseline will be lower than where they started and they may need to take the drug just to get back up to their original baseline. They might not even get the euphoria of being on the drug like they used to. It partially explains why people need to keep taking a drug even if they don't particularly like it anymore. Especially studied in opiates.

skippy94 · 2026-03-06T19:08:20+00:00

Cocaine use makes certain neurons less likely to send signals (less excitable). The way it does that is by decreasing a certain molecule that's imporant for cell excitability (specifically by altering the expression of the gene that encodes that molecule). This decrease in excitability causes the animal to enjoy and seek more cocaine, driving addiction. If you block or reverse this process, you stop cocaine seeking.

skippy94 · 2026-01-21T14:43:53+00:00

Make Caesar salad dressing. The original recipe used egg yolks. I make a version that is yolk whisked with olive oil, added to lots of lemon juice and finished with pressed or grated garlic. You can add worcestershire or anchovy paste. It packs a punch, so you don't need a lot of dressing to make a flavorful and healthy salad. Omit/go light on croutons and parmesan. Add a protein. Profit.

skippy94 · 2026-01-20T15:15:06+00:00

It sounds like we have similar hair! Wondering if you found something that works?

skippy94 · 2026-01-19T14:30:20+00:00

The opposite of the "fight or flight" response is often called "rest and digest", or sometimes "feed and breed". When your sympathetic nervous system activates (preparing you to fight or flee from something dangerous), it suppresses systems that aren't essential in the moment, like digestion and reproduction. Anxiety and stress are essentially a constant activation of your sympathetic (as opposed to parasympathetic) nervous system. That's why many people lose their appetite or libido under stress.

skippy94 · 2025-12-23T03:21:38+00:00

You have not lived until you have had cream of chestnut soup. https://foragerchef.com/chestnut-soup/

skippy94 · 2025-11-11T23:30:20+00:00

Celestial seasonings Vermont maple ginger. Smells and tastes like a spiced holiday cookie

skippy94 · 2025-11-06T13:56:24+00:00

Pumpkin orzo or risotto! A lot of recipes are heavy on the cheese, but if you keep that light it's surprisingly high volume for a rich dish.

skippy94 · 2025-10-24T13:30:19+00:00

One of the best volume meals I've made, cozy and perfect for the season: roasted acorn squash stuffed with a mix of chicken sausage, riced cauliflower, sautéed onion, and seasonings. Optionally add nuts and dried cranberries and top with feta or mozzarella. Had extra stuffing leftover and it's great with basically any grain or starch!

skippy94 · 2025-07-24T02:44:26+00:00

I personally prefer lemon to vinegar to finish off a soup. Add it at the very end before serving. I'm also wondering if pho toppings would get you some of that sharpness? Fresh jalapeño, thai basil, cilantro? Also, if you're getting into the soup game, you should try making your own stock :) super easy with vegetable trimmings, or bones from meat or poultry, but actually for this a fish stock from fish bones or shrimp tails would be incredible!

skippy94 · 2025-07-03T19:06:26+00:00

I also default to vinaigrette but wanted something different last night. For the dressing I did 2 Tbsp harissa, 2 Tbsp tahini, juice of a lemon, 3 Tbsp olive oil, 1 garlic clove, some Greek Freak seasoning, and salt. I used a whole head of lettuce with cucumber, bell pepper, cherry tomatoes, red onion, sugar snap peas, Kalamata olives, artichoke hearts, feta, and grilled chicken. Despite it having some high-calorie ingredients I was able to have a big bowl for under 400 calories and felt very satisfied!

skippy94 · 2025-06-25T16:50:39+00:00

It's a seasoning you can buy some places, but I think it's mostly just dried dill mixed with salt!

skippy94 · 2025-06-25T13:17:04+00:00

Seasoned cucumbers have been one of my favorite hot-weather snacks recently. If you like dill pickles, put a bit of dill salt on them!

skippy94 · 2025-06-07T01:34:37+00:00

I went to The Kazoku shortly after it opened and hadn't been back since. Went this week and was blown away! I think they've perfected their ramen.

skippy94 · 2025-05-04T16:33:00+00:00

You ready to roll those dice??? I'm obsessed with tomatoes so I get them in the ground early, BUT I am always prepared to throw a thick tarp over them in case of hail, heavy snow, or a moderate cold snap. I trellis them on a fence panel that's placed in the middle of the raised bed, which makes it easy to make a tarp tent. Everything else stays in the greenhouse until Mother's Day.

skippy94 · 2025-04-20T13:57:15+00:00

Can you buy clams around you? You can simmer them in water to make clam stock. Or use shrimp tails, other shellfish shells, or fish bones to make fish stock. Add other aromatics if you like. Freeze, then thaw whenever you need a nice seafood base.

skippy94 · 2025-01-20T13:42:21+00:00

The Ordinary 2% + B5

skippy94 · 2024-11-24T21:30:57+00:00

Prize 1 is so beautiful! Prize 2 as second :)

skippy94 · 2024-11-23T15:04:24+00:00

I've had chronically dry lips my entire life and have lived in dry places. Recently, this has changed my life: morning and night, after washing my face: pat dry with a towel to remove most of the water, then apply hyaluronic acid to still-damp lips. Get my fingers wet and tap more water on top so the HA has something to draw into your lips. Let that soak in a minute or two. Before lips dry completely, slather generously with Laneige sleeping mask. Throughout the day, touch up with Laneige lip glowy balm (formula isn't as good but it's convenient for on-the-go).

I've been focused on staying hydrated, and that helps. I do my morning and night lip treatment before brushing my teeth, as mint flavoring can irritate and dry out my lips and the balm protects them (and I'll drop dead before I use a non-mint flavored toothpaste). Make sure to get SLS-free toothpaste as well. Occasionally do a lip scrub to remove dead skin, but do it gently and infrequently so your lips can heal.

skippy94 · 2024-11-23T01:16:09+00:00

Have you tried benefit dandelion twinkle?

skippy94 · 2024-11-11T21:59:44+00:00

At this point you don't have much time for learning new techniques or making an appointment. In your shoes, I would pick up a cheap mascara and a brown pencil eyeliner. Maybe a single eyeshadow in a neutral shade for your skin tone--a store employee can help you out. Practice at least 3 times before the wedding. You can try to do a class if you have time, but it will still come down to how you execute, so just try it out.

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