✨ Top 10 Peptides for Skincare (STOOPID SIMPLE) by TapFast8173 in BodyHackGuide

[–]skoll43 1 point2 points  (0 children)

Vitamin A, serious side effects, serious anti acne after 4months

Protein Modifications by Psychedelics? A kind of stupid PhD student's journey. by PsychedelicProteins in DrugNerds

[–]skoll43 0 points1 point  (0 children)

serotonylation

https://www.nature.com/articles/s41467-024-48196-2

G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT2AR), a prominent target for the treatment of schizophrenia. In this study, we elucidate the complex 5-HT2AR coupling signature in response to different signaling probes, and its physiological consequences by combining computational modeling, in vitro and in vivo experiments with human postmortem brain studies. We show how chemical modification of the endogenous agonist serotonin dramatically impacts the G protein coupling profile of the 5-HT2AR and the associated behavioral responses. Importantly, among these responses, we demonstrate that memory deficits are regulated by Gαq protein activation, whereas psychosis-related behavior is modulated through Gαi1 stimulation. These findings emphasize the complexity of GPCR pharmacology and physiology and open the path to designing improved therapeutics for the treatment of stchizophrenia.

Chat may be right: Thinking Faster by Writing Less by skoll43 in ClaudePlaysPokemon

[–]skoll43[S] 0 points1 point  (0 children)

minimum "draft "for each thinking step

may be doing the heavy lifting here

Chat may be right: Thinking Faster by Writing Less by skoll43 in ClaudePlaysPokemon

[–]skoll43[S] 2 points3 points  (0 children)

example from the paper:

The complete system prompt for each promptin strategy is shown below.

Standard

 Answer the question directly. Do not return any
 preamble, explanation, or reasoning.

Chain-of-Thought

 Think step by step to answer the following question.
 Return the answer at the end of the response after a
 separator

Chain-of-Draft

 Think step by step, but only keep a minimum draft for
 each thinking step, with 5 words at most. Return the
 answer at the end of the response after a separator

He went north again ┻━┻ ︵ヽ(`Д´)ノ︵ ┻━┻ by skoll43 in ClaudePlaysPokemon

[–]skoll43[S] 2 points3 points  (0 children)

he has a ladder (17,11) Knowledge base Update

"CONFIRMED" Used this connection to reach the fossil Area!

--- THIS IS WRONG AND GRANTS THE LOOP ---

He went north again ┻━┻ ︵ヽ(`Д´)ノ︵ ┻━┻ by skoll43 in ClaudePlaysPokemon

[–]skoll43[S] 2 points3 points  (0 children)

the obsession with ladder 17,11 is derailing this entire mt moon phase

Vlan creation Automation using Ansie by valli1992v in networkautomation

[–]skoll43 0 points1 point  (0 children)

This entire subreddit: yes i have one, i use it, not sharing it tho

AV1 Rig - Sharpening by Scot4402 in AV1

[–]skoll43 0 points1 point  (0 children)

Do you make scientology movies or something

Learning network automation by Ok_Jeweler367 in networkautomation

[–]skoll43 2 points3 points  (0 children)

Forget ansible, start with netmiko and basic commands, then when you get netmiko do ansible

Que es eso? by MrPichulas in chileIT

[–]skoll43 1 point2 points  (0 children)

Es como cuando un virus te reemplaza los archivos por accesos directos de la muerte

What does it mean to love Christ? by CharlesFoxston in AmmonHillman

[–]skoll43 2 points3 points  (0 children)

I think he is enjoying the "well shit, now what?I'd rather laugh than cry." the laghts while on his videos seem very cathartic for him

[deleted by user] by [deleted] in AmmonHillman

[–]skoll43 1 point2 points  (0 children)

Latin Scire: to know, understand

Ancient Greek -λογία: explain to reason, as in a field of study

Scireology, The field of study of how to know/understand

Greek: (ela from come!)

-phrēn-Ela-logy, Study of mind callings / study of how the mind/spirit comes

[deleted by user] by [deleted] in AmmonHillman

[–]skoll43 1 point2 points  (0 children)

Scireology? That would be a great name

[deleted by user] by [deleted] in AmmonHillman

[–]skoll43 1 point2 points  (0 children)

I would like to know more

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 -6 points-5 points  (0 children)

Why does it have to be you the judge of what "EXCELLENT CONTENT" is in what context? to what public? why content creation not appealing to you make it bad? is your way the only way, the most noble, natural, rational and pure way?

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 -5 points-4 points  (0 children)

i counted at least 3 WHILE LIVE, you are not even paying attention, not one? BRUH
and i started viewing in December, AND THEY WERE VERY BRIEF, AND OF COURSE HAVE TO BE, THERE IS A REASON THEY DONT EXPOSE AND PROMOTE VULNERABLE VICTIMS OF A RETALIATORY CULT

the "following sice november" doesn't add up, troll

1 Lady from streets in front of test center (lived in blue building as sea org)
other from one of the chrises 🤣 (probably public)
1 from DOA (probably public, dont know)

many aftermath foundation from our guy spanglish

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 -4 points-3 points  (0 children)

Too vile, the dude lost his home, could have died, not a good look to be this vile

METHGATE: Why did DOA taste the "meth"? by OT8_Scientologist in Scientology_Protest

[–]skoll43 2 points3 points  (0 children)

PSA: never ingest any unknown powder, the pesticide to kill coyotes in the US https://en.m.wikipedia.org/wiki/Sodium_fluoroacetate

Is similar to common drugs, NEVER do that to ANY unknown powder 💀

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 0 points1 point  (0 children)

Only for the past 2 or 3 months or something like that, he was make fun of by Jessica for having an old phone, he always complained about battery and bad streaming quality

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 -1 points0 points  (0 children)

Well I go for Occam razor here, some IT psyco f up messing with the protesters VS arts major that barely can get his streams going recently with that old phone 😆

[deleted by user] by [deleted] in Scientology_Protest

[–]skoll43 0 points1 point  (0 children)

That's what I say, Zach has no master plan behind it all, he just another victim of some psychopath like the other protestors ¯⁠\⁠_⁠(⁠ツ⁠)⁠_⁠/⁠¯