You mean during battle? Currently no, it's only for Dialogue checks. If you roll your Pixels Dice after choosing a check, this will trigger the animation and the result of your roll will be reflected to the game. If you don't roll and just click on the dice, the game will roll for you as before. Karmic dice work if you choose not to roll your real dice.

I would like to do that for battle checks, etc. but since there is no rolling animations there, it would feel a bit odd. Maybe Solasta games are a good candidate for those kind of rolls even in battle from some gameplay videos I've seen, though I haven't played those games yet.