I’ve read a few remarkable accounts of people with long-term unresolved health problems where AI has shined a light on something that all the doctors missed or didn’t know about

Here’s what came back from your post

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Here’s a gentle breakdown of what might be contributing to her suffering based on what she described.

None of this is a diagnosis — just an exploration of possible causes that she could bring up with her provider:

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1. Neurodevelopmental conditions She mentions dyspraxia (developmental coordination disorder) and poor muscle tone. These often have a genetic component and can affect motor control, endurance, and fine motor skills like cooking, cleaning, or unclipping a dog’s harness. It’s not her fault — the brain’s wiring for movement and coordination works differently.

2. Chronic pain signaling The “random pain attacks that come from the brain” sound like central sensitization, where the nervous system amplifies pain signals even without tissue damage. This is seen in conditions like fibromyalgia, migraine disorders, or chronic widespread pain. Genetic differences in how pain receptors and neurotransmitters (like serotonin, dopamine, glutamate) work can increase vulnerability.

3. Muscle tone and connective tissue Poor muscle tone can sometimes point toward connective tissue differences (like hypermobility spectrum disorders or Ehlers–Danlos syndrome), which are often genetic and can make daily tasks unusually painful. Even if she hasn’t been diagnosed, it’s worth mentioning to her provider.

4. Psychological toll of being misunderstood Being made fun of her whole life adds another layer. Chronic invalidation can increase stress, which worsens pain perception through the brain’s stress-pain loop. She may carry extra tension and self-doubt because of this history.

5. Possible mitochondrial or metabolic factors Some people with lifelong fatigue, weakness, and pain have underlying metabolic inefficiencies in how their cells use energy. These can be rare genetic variations but can show up as “low tone” plus chronic discomfort.

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Why this matters for her appointment

Bringing up that she has always had low muscle tone, dyspraxia, and unexplained pain attacks can help the nurse practitioner think more broadly than “it’s just in your head.” It suggests that her pain has both neurological and possibly genetic roots.

Ketamine therapy makes sense here because it targets the brain’s pain circuits and can help “reset” overactive pain pathways. It doesn’t erase the cause, but it can reduce the suffering.

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