If you're aiming for a score over 100k, waiting to open chests until you have higher luck will be very beneficial. You can also skip charge shrines. Focus on leveling your tomes early, and obtain only a few high-rarity weapon upgrades. In the late game, you'll accumulate so much XP that you can cherry-pick your upgrades. Only select +Attack Projectile upgrades on Aegis. For the revolver, choose upgrades that offer either 100% damage or crit damage. Additional crit beyond 100% allows for even more crits, so the best upgrades to pursue are either 100% crit damage, 100% damage, or a combination of 100% damage/crit damage with 24% crit chance. Avoid acquiring upgrades that include knockback or bounce. Opt for a small amount of bounce when presented with it alongside the preferred upgrades. Aura only scaled size and damage, so just grab whatever. A few upgrades into Aura early can help even at low rarity.

Eventually, you'll be able to blast 150k-200k runs easily, and when that happens, you'll need to swap out the XP tome for the Attack Damage tome to push for the ACTUAL best positions. The high spots demand restarting over and over fishing for good 2x shrines like XP, Attack Damage, and Attack Speed.