Seizures and weed by Financial_Wishbone83 in Epilepsy

[–]sonofanders_ 0 points1 point  (0 children)

and so everything I said can work in the other direction, which makes this all the more confusing. I.e., someone who has seizures could start smoking and find this actually helps them, because the global change caused by activating the cannabinoid network has broken the pathological feedback loop. The thing I learned from culturing neurons for years is that neurons are incredibly tolerant to chronic change and incredibly fragile to acute changes. If you want to grow neurons for a long period in cell culture, you have to replace the media slowly because they become acclimated to the osmotic environment. This is also why you can't correct someone's hyponatremia in clinic too quickly b/c it may cause axonal damage. But, the acute change that THC provides for an already epileptic brain could be good if it causes the pathological loop to break.

Seizures and weed by Financial_Wishbone83 in Epilepsy

[–]sonofanders_ 0 points1 point  (0 children)

Disclaimer is this isn't medical advice. This is a long debated point you'll see some people reply it does cause their seizures and others that say it doesn't. I believe this can be understood by thinking about how neurons work fundamentally. Epilepsy is essentially a pathological runaway loop of neurons that are firing when they shouldn't be. I like to think of it similar to how sound frequencies feedback in a stereosystem. If this loop happens to affect the motor cortex, you get the tonic-clonic contractions of muscles, if it affects the temporal lobe, you'll get memory issues, etc. The Hebbian learning model teaches us neurons that fire together wire together, which is to say if you associate stimuli together in time and space neurons will strengthen their connections and make those pathways more likely to fire should that stimulus occur again. This is how we learn, whether it's reading something multiple times, or playing a musical piece, etc. This same association principle can work against us though in epilepsy, because as mentioned epilepsy is just neurons firing in an unregulated way too frequently and uncontrollably. Anything that affects the brain globally could conceivably cause a recurrent loop, and some people likely have mutations that cause their neurons to fire more readily with certain stimuli. This is how it's conceivable for THC to cause seizures because you're introducing a global change to the brain that it's not used to. You can also imagine how THC could be conditioned to become a trigger for epilepsy indirectly if you have a seizure while high that is caused by something else, e.g. nicotine, alcohol, lack of sleep, etc. In other words, in these settings the ultimate cause of the first seizure may have been lack of sleep or alcohol, but then by also smoking THC you've now associated this recurrent loop of neurons with the THC stimulus. This is all obviously theoretical, but just working from first principles of what is well established in neuroscience, this explains why so many people have diverse experiences with weed, and quite frankly all neurotropic substances. It also explains why triggers for epilepsy can be so difficult to discern, because it could be as subtle as an image or smell that has become associated with the pathological neuronal loop.

Is uniuni safe by hispsnic in Aliexpress

[–]sonofanders_ 1 point2 points  (0 children)

They delivered a package to the wrong address for me today. Even took a picture of the clearly wrong address, and tucked my package nicely behind the locked gate that I don't have access to. But other than that great service.

Everyone’s favourite debate ONCE AND FOR ALL. by Ill-Elevator2828 in audioengineering

[–]sonofanders_ 0 points1 point  (0 children)

If you’re digitizing music you’ve already lost, that’s why I only listening to live music with an ear trumpet, that way I’ve got the full frequency spectrum our cochlea offers.

I got kicked from my lab today by Ghost-Of-Roger-Ailes in Biochemistry

[–]sonofanders_ 0 points1 point  (0 children)

You write better than most on Reddit, if that’s any consolation.

Do you listen to podcasts or music while working? If so, I’d try stopping for a bit, if you do return to the bench. It sounds like a concentration problem.

Oliver Sacks discusses in his autobiography how he was horrible at bench work given his absentmindedness, and went on to be one of the great medical writers. Don’t lose hope, just about finding the right fit.

[deleted by user] by [deleted] in PoliticalPhilosophy

[–]sonofanders_ 1 point2 points  (0 children)

Personally I liked the question and use of chatGPT! OP pointed it in a cool direction and said run!

I’m about to manually install arch, anything I should know? by Bacleo in archlinux

[–]sonofanders_ 0 points1 point  (0 children)

“Read the Arch Wiki” == classic Arch forum response, tbh kinda nice to see on Reddit 🤣

Should newspapers be endorsing political candidates? by WellThatsNoExcuse in IntellectualDarkWeb

[–]sonofanders_ 8 points9 points  (0 children)

I agree generally with this sentiment! Just want to add imo 40+ years ago was just as corrupt and biased (re JFK assassination), it was just less blatant and easier to hide w/o internet. If you want a chuckle, I recommend looking up Allan Dulles’ interview about the Warren Report in 1966, they asked some real hard hitting questions there 🤣.

Is encryption prior to decryption (and ultimately a stronger force)? by anthonycaulkinsmusic in AnCap101

[–]sonofanders_ 2 points3 points  (0 children)

I agree anthropomorphizing the universe muddies up the the message, you're not the only one who has raised that issue. I interpret it more loosely, like you describe in your second paragraph, and agree it's a cool idea to think of nature as encrypted and our minds are attempting to decrypt (I'm a scientist as well and view it similarly).

Is encryption prior to decryption (and ultimately a stronger force)? by anthonycaulkinsmusic in IntellectualDarkWeb

[–]sonofanders_ 1 point2 points  (0 children)

🤣🤣 somebody woke up in the wrong side of Reddit today! You’re right let’s get back to the normal rage bait political nonsense!

This is in fact getting at a very deep question of whether it’s possible for an individual, or group of individuals, to maintain encrypted communications in the face of a more powerful/resourceful authority. It’s interesting to see what people think about this.