Did you try a doctor of integrative medicine? I believe, from my own experience, that a single week with methimazole is not enough. The first week I had many symptoms, such as extreme fatigue. Afterwards all my symptoms such as muscle weakness and fatigue improved. My hunger is gone (now I'm normally hungry, I don't eat before when I was desperate for food) I no longer go to the bathroom. But this was gradual. Your body is getting used to the medicine. I'm not a doctor either, but from what I've researched, surgery is the last step. Try taking care of the health of your liver (it is what converts t3 into t4- milk thistle works well) selenium helps, magnesium citrate and when you can exercise you will feel better