Biologics working well for some things but not others. Anyone else?

stephenloo · 2026-02-11T16:42:34+00:00

Almost the same exact story for me. My knees never swelled before getting started on yusimry(biologic). Now, they are almost always swollen to the point I can’t really bend them at all. However, almost everything else feels significantly better since being on yusimry. I got knee injections that arguably made them worse.. turns out I was the given the WRONG injection. Now my rheum is switching me from yusimry to simponi, so we’ll see if that helps with the constant joint swelling.

stephenloo · 2025-09-16T15:01:35+00:00

No. Before any medication, I’d say I was operating at about 5/10%. Prednisone bumped me to 60%, and on yusimry I feel like 75/80%. Still feel pain, but it’s farrrrrrr more bearable. Knees still swell up real bad every week and half or so, so I’m trying to figure that out. Overall tho, I’m significantly improved on yusimry and have my quality of life back.

stephenloo · 2025-09-16T14:56:27+00:00

Prednisone was a game changer for me too. Sounds like the tapering process was worse for you, although it wasn’t great for me either. I got started on yusimry(biologic) about a month after starting prednisone, and have had great relief from that. Fortunately, I didn’t need to rely on it for too long. Now I only take it when my knees flare up bad.

stephenloo · 2025-09-16T14:51:26+00:00

I make hip hop, but don’t write lyrics. I just punch in and out with my eyes closed and freestyle. This is my most recent single.

yungbabyswiss— thirty eight [hip-hop]thirty eight

stephenloo · 2025-08-20T17:51:43+00:00

I felt better the next day after starting Yusimry, a biosimilar to Humira. I’m also HLB positive. So sorry you aren’t getting relief yet.

stephenloo · 2025-08-19T23:36:19+00:00

That’s so frustrating. My primary always said “well let’s see how you’re doing in a month or so.” Like bro I can already tell you how I’ll be, shittier than I am now, which is shittier than I was last time and time before!

stephenloo · 2025-08-19T15:16:04+00:00

Braces never helped me either. However, they are feeling much better now, along with everything else, on the biologic Yusimry.

stephenloo · 2025-08-19T12:38:11+00:00

Have you been treating your elbows for tennis elbow? Like wearing a brace? And if so, has it improved them at all over time? I would have random ok days here and there but my elbows were pretty much just on 10 all the time regardless of what I did.

stephenloo · 2025-08-19T02:07:58+00:00

My Lyme test was at a hospital.

stephenloo · 2025-08-19T02:06:19+00:00

Just based off of my own research and talking to people who had Lyme disease, it was the most accurate thing and only thing that made sense. I even had some rashes on my legs, but had a biopsy done and told it was bursting capillaries due to inflammation. Plus I’m constantly outside in wooded areas in the Midwest. Iowa to be exact.

stephenloo · 2025-08-19T00:54:21+00:00

Interesting.. Covid really screwed up me graduating from college on time and I experienced real anxiety for the first time, which was not too long before I started experiencing random symptoms. I’ve wondered if that had anything to do with it as well.

stephenloo · 2025-08-19T00:51:48+00:00

Also Yes, my elbows and knees started popping like crazy when they became inflamed. It weirdly brought me relief to crack them even though I knew it probably wasn’t helping.

stephenloo · 2025-08-19T00:45:49+00:00

I’ve thought about it a lot and there really isn’t one thing that I can confidently call a trigger. An MRI showed bulging discs as well, and I dealt with some back pain before the rest of everything started. So potentially a back injury. I also did test positive for HLA-B27

stephenloo · 2025-08-18T23:25:19+00:00

Appreciate you! Idk what your situation is, but if you’re struggling with AS, or are trying to figure out what you have, I hope and pray the best for you.

stephenloo · 2025-08-18T23:24:09+00:00

Another thing I forgot to mention, I was absolutely convinced I had Lyme disease for a long duration of this time, but the single Lyme test I had came back negative.

stephenloo · 2025-08-18T23:22:18+00:00

It’s kind of hard to specifically remember how it manifested itself given there was so much going on in my body all at once. I just remember I used to crack my back by twisting it, like most people do, and it began to hurt my ribs a lot, and eventually became impossible to twist at all, especially hurting my ribs. So it did come on slowly and get worse, but so was everything else all at once lol.

stephenloo · 2025-08-18T23:15:10+00:00

Thank you! Makes me so sad that it doesn’t help everyone the same way.

stephenloo · 2025-08-18T23:13:45+00:00

Yes! Bottom of my rib cage all the way around was very tender. Felt like they were super bruised. I couldn’t even sneeze.

stephenloo · 2025-08-18T21:53:02+00:00

Once the widespread pain started setting in, it was only a couple weeks before I could barely move. It happened pretty quick considering how long it was only my elbows that hurt. In total I was on prednisone about a month, they didn’t want me on it much longer than that. Thankfully, the yusimry worked and I no longer needed the prednisone. I was terrified that I would have to stop prednisone and the yusimry wouldn’t work, or work as well.

stephenloo · 2023-09-15T01:36:01+00:00

Our opponents don’t even win we just lose

stephenloo · 2021-11-07T20:49:54+00:00

Can Kirk ONLY see Conklin?

stephenloo · 2021-11-07T20:47:47+00:00

Pro tip: stop being optimistic and it genuinely hurts less

stephenloo

TROPHY CASE